TY - JOUR
T1 - TGF-beta induces telomerase-dependent pancreatic tumor cell cycle arrest
AU - Cassar, Lucy
AU - Li, He
AU - Jiang, Fang -Xu
AU - Liu, Jun-Ping
PY - 2010
Y1 - 2010
N2 - To investigate the relationship between TGF- and TERT in
regulating tumor cell proliferation, we hypothesized that TGF-
regulation of the cell cycle progress is mediated by mechanisms
involving TGF- regulation of the downstream target gene TERT.
In the present study, we demonstrate that TGF- -induced pancreatic
tumor cell apoptosis is inhibited by TERT over-expression in
pancreatic cancer cells.
AB - To investigate the relationship between TGF- and TERT in
regulating tumor cell proliferation, we hypothesized that TGF-
regulation of the cell cycle progress is mediated by mechanisms
involving TGF- regulation of the downstream target gene TERT.
In the present study, we demonstrate that TGF- -induced pancreatic
tumor cell apoptosis is inhibited by TERT over-expression in
pancreatic cancer cells.
UR - http://www.sciencedirect.com/science/article/pii/S0303720710000602
U2 - 10.1016/j.mce.2010.02.002
DO - 10.1016/j.mce.2010.02.002
M3 - Article
SN - 0303-7207
VL - 320
SP - 97
EP - 105
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
ER -
