TGF-beta induces telomerase-dependent pancreatic tumor cell cycle arrest

Lucy Cassar, He Li, Fang -Xu Jiang, Jun-Ping Liu

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15 Citations (Scopus)

Abstract

To investigate the relationship between TGF- and TERT in regulating tumor cell proliferation, we hypothesized that TGF- regulation of the cell cycle progress is mediated by mechanisms involving TGF- regulation of the downstream target gene TERT. In the present study, we demonstrate that TGF- -induced pancreatic tumor cell apoptosis is inhibited by TERT over-expression in pancreatic cancer cells.
Original languageEnglish
Pages (from-to)97 - 105
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume320
DOIs
Publication statusPublished - 2010

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