Tetrodotoxin-sensitive action potentials in smooth muscle of mouse vas deferens

Mollie E. Holman, Mary Anne Tonta, Helena C. Parkington, Harold A. Coleman

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Action potentials were recorded during impalements of some but not all smooth muscle cells of mouse vas deferens in response to both nerve stimulation and intracellular current injection. They were resistant to blockade by nifedipine (0.1-1.0 μM) but were blocked by tetrodotoxin (TTX, 0.2-1.0 μM) when this was added in the presence of nifedipine. It is suggested that voltage-dependent sodium (Na+) channels are present in mouse vas deferens that function to amplify calcium (Ca2+) influx through voltage-dependent Ca2+ channels.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalJournal of the Autonomic Nervous System
Issue number2-3
Publication statusPublished - 8 Apr 1995


  • Action potential
  • Excitability
  • Neurotransmission
  • Smooth muscle
  • Sodium channel

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