To determine the efficacy of tenofovir disoproxil fumarate (TDF) in adults with chronic hepatitis B virus (HBV) infection who had previously failed lamivudine (LAM) and had significant viral replication (HBV DNA >10a?? copies/ml if HBeAg positive, > 10a? copies/ml if HBeAg negative) despite at least 24 weeks of treatment with adefovir dipivoxil (ADV).
Patterson, S., George, J., Strasser, S., Lee, A., Sievert, W., Nicoll, A., Desmond, P., Roberts, S., Locarnini, S., Bowden, S., & Angus, P. (2011). Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B. Gut, 60(2), 247 - 254. https://doi.org/10.1136/gut.2010.223206