Ten years experience of Salmonella infections in Cambridge, UK

Nicholas Matheson, Robert A. Kingsley, Katherine Sturgess, Sani H. Aliyu, John Wain, Gordon Dougan, Fiona J. Cooke

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47 Citations (Scopus)

Abstract

Objectives: Review of all Salmonella infections diagnosed in the Cambridge area over 10 years. Methods: All Salmonella enterica isolated in the Clinical Microbiology Laboratory, Addenbrooke's Hospital between 1.1.1999 and 31.12.2008 were included. Patient demographics, serotype and additional relevant details (travel history, resistance-type, phage-type) were recorded. Results: 1003 episodes of Salmonella gastroenteritis were confirmed by stool culture, representing 88 serotypes. Serotypes Enteritidis (59%), Typhimurium (4.7%), Virchow (2.6%), Newport (1.8%) and Braenderup (1.7%) were the 5 most common isolates. There were an additional 37 invasive Salmonella infections (32 blood cultures, 4 tissue samples, 1 CSF). 13/15 patients with Salmonella Typhi or Salmonella Paratyphi isolated from blood or faeces with an available travel history had returned from the Indian subcontinent. 8/10 S. Typhi or Paratyphi isolates tested had reduced susceptibility to fluoroquinolones (MIC ≥ 0.125 mg/L). 7/21 patients with non-typhoidal Salmonella bacteraemia were known to be immunosuppressed. Conclusion: This study describes Salmonella serotypes circulating within a defined geographical area over a decade. Prospective molecular analysis of isolates of S. enterica by multi-locus sequence typing (MLST) and single nucleotide polymorphism (SNP) detection will determine the geo-phylogenetic relationship of isolates within our region.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalJournal of Infection
Volume60
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010
Externally publishedYes

Keywords

  • Antibiotic resistance
  • Enteric fever
  • Epidemiology
  • Fluoroquinolones
  • Gastroenteritis
  • Paratyphoid fever
  • Salmonella enterica
  • Typhoid fever

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