Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion

Robert E. Widdop, Elena Krstew, Bevyn Jarrott

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The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarized the nodose ganglion, both at room temperature (20-24°C) and at 35-37°C. However, A II depolarised the nodose ganglion only under the latter condition, and these responses were blocked by the A II receptor antagonist saralasin. This study extends previous findings which have demonstrated A II binding sites on the nodose ganglion and axon, and identifies the rat nodose ganglion as a sensitive preparation in which to study the interactions between neuronal A II receptor activation and its blockade by A II receptor antagonists.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - 21 Aug 1990
Externally publishedYes


  • (Rat)
  • 5-HT (5-hydroxytryptamine, serotonin)
  • Angiotensin II
  • Depolarisation
  • Nodose ganglion
  • Saralasin
  • Temperature sensitivity

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