TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity

Taras Kreslavsky, Adam K. Savage, Robin Hobbs, Fotini Gounari, Roderick Bronson, Pablo Pereira, Pier Paolo Pandolfi, Albert Bendelac, Harald Von Boehmer

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173 Citations (Scopus)

Abstract

Some γδ and αβ T lymphocytes exhibit an "innate" phenotype associated with rapid cytokine responses. The PLZF transcription factor is essential for the innate phenotype of NKT cells. This report shows that PLZF is likewise responsible for the innate, NKT-like phenotype of Vγ1+Vδ6.3/Vδ6.4+ cells. TCR cross-linking induced PLZF expression in all polyclonal immature γδthymocytes, suggesting that agonist selection might be required for PLZF induction. Transgenic expression of Vγ1Vδ6.4 TCR was sufficient to support the development of large numbers of PLZF+ T cells, further supporting the importance of the TCR for PLZF induction. Interestingly, expression of this TCR transgene led to the development of spontaneous dermatitis.

Original languageEnglish
Pages (from-to)12453-12458
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number30
DOIs
Publication statusPublished - 28 Jul 2009
Externally publishedYes

Keywords

  • Agonist selection
  • Innate T cells
  • Transgenes

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