TCF-1 at the Tfh and Th1 Divergence

Crystal Yaping Chen; Di Yu

doi:10.1016/j.it.2015.11.001

TCF-1 at the Tfh and Th1 Divergence

Crystal Yaping Chen, Di Yu

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short Survey › Other › peer-review

11 Citations (Scopus)

Abstract

Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1 lineages. ? 2015 Elsevier Ltd.

Original language	English
Pages (from-to)	758-760
Number of pages	3
Journal	Trends in Immunology
Volume	36
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2015.11.001
Publication status	Published - 2015

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10.1016/j.it.2015.11.001

Cite this

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title = "TCF-1 at the Tfh and Th1 Divergence",

abstract = "Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1 lineages. ? 2015 Elsevier Ltd.",

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AU - Yu, Di

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AB - Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1 lineages. ? 2015 Elsevier Ltd.

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DO - 10.1016/j.it.2015.11.001

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JO - Trends in Immunology

JF - Trends in Immunology

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TCF-1 at the Tfh and Th1 Divergence

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Immune balance-regulating interleukins as targets for immunotherapy

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TCF-1 at the Tfh and Th1 Divergence

Abstract

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Immune balance-regulating interleukins as targets for immunotherapy

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