Targeting toll-like receptors for drug development: a summary of commercial approaches

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Abstract

Toll-like receptors (TLRs) play a fundamental role in recognizing infectious and noxious agents as well as products of tissue damage. They are capable of initiating both protective and damaging inflammatory and immune responses. Several biotechnology and pharmaceutical companies have programmes to develop new drugs that are either: agonists of TLRs to enhance immune responses against tumours and infectious agents, or to correct allergic responses; or antagonists designed to reduce inflammation due to infection or autoimmune disease. This article reviews the commercial approaches being undertaken to develop new TLR drugs.
Original languageEnglish
Pages (from-to)490 - 494
Number of pages5
JournalImmunology and Cell Biology
Volume85
Issue number6
Publication statusPublished - 2007

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