Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Karina Huynh, Helen Kiriazis, Xiao-Jun Du, Jane E Love, Stephen P Gray, Karin Agnes Maria Jandeleit-Dahm, Julie Rae McMullen, Rebecca H Ritchie

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Abstract

Wetestedthehypothesisthattargetingleft-ventricular(LV)reactiveoxygenspecies (ROS)upregulationsubsequenttohyperglycemiaattenuatestype1diabetes-inducedLVremodelingand dysfunction, accompaniedbyattenuatedproinflammatory markersandcardiomyocyteapoptosis
Original languageEnglish
Pages (from-to)307 - 317
Number of pages11
JournalFree Radical Biology and Medicine
Volume60
DOIs
Publication statusPublished - 2013

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