Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections

Abigail Clements, Adam W Jenney, Jacinta L Farn, Lorena Elizabeth Brown, Georgia Deliyannis, Elizabeth Louise Hartland, Martin J Pearse, Margaret B Maloney, Steven Lodewyk Wesselingh, Odilia LC Wijburg, Richard Strugnell

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge with K. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimental K. pneumoniae infection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains of K. pneumoniae.
Original languageEnglish
Pages (from-to)5649 - 5653
Number of pages5
JournalVaccine
Volume26
Issue number44
Publication statusPublished - 2008

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