Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections

Abigail Clements; Adam W Jenney; Jacinta L Farn; Lorena Elizabeth Brown; Georgia Deliyannis; Elizabeth Louise Hartland; Martin J Pearse; Margaret B Maloney; Steven Lodewyk Wesselingh; Odilia LC Wijburg; Richard Strugnell

Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections

Abigail Clements, Adam W Jenney, Jacinta L Farn, Lorena Elizabeth Brown, Georgia Deliyannis, Elizabeth Louise Hartland, Martin J Pearse, Margaret B Maloney, Steven Lodewyk Wesselingh, Odilia LC Wijburg, Richard Strugnell

Microbiology

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge with K. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimental K. pneumoniae infection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains of K. pneumoniae.

Original language	English
Pages (from-to)	5649 - 5653
Number of pages	5
Journal	Vaccine
Volume	26
Issue number	44
Publication status	Published - 2008

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Clements, Abigail ; Jenney, Adam W ; Farn, Jacinta L ; Brown, Lorena Elizabeth ; Deliyannis, Georgia ; Hartland, Elizabeth Louise ; Pearse, Martin J ; Maloney, Margaret B ; Wesselingh, Steven Lodewyk ; Wijburg, Odilia LC ; Strugnell, Richard. / Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections. In: Vaccine. 2008 ; Vol. 26, No. 44. pp. 5649 - 5653.

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abstract = "Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge with K. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimental K. pneumoniae infection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains of K. pneumoniae.",

author = "Abigail Clements and Jenney, {Adam W} and Farn, {Jacinta L} and Brown, {Lorena Elizabeth} and Georgia Deliyannis and Hartland, {Elizabeth Louise} and Pearse, {Martin J} and Maloney, {Margaret B} and Wesselingh, {Steven Lodewyk} and Wijburg, {Odilia LC} and Richard Strugnell",

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journal = "Vaccine",

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Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections. / Clements, Abigail; Jenney, Adam W; Farn, Jacinta L; Brown, Lorena Elizabeth; Deliyannis, Georgia; Hartland, Elizabeth Louise; Pearse, Martin J; Maloney, Margaret B; Wesselingh, Steven Lodewyk; Wijburg, Odilia LC; Strugnell, Richard.

In: Vaccine, Vol. 26, No. 44, 2008, p. 5649 - 5653.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections

AU - Clements, Abigail

AU - Jenney, Adam W

AU - Farn, Jacinta L

AU - Brown, Lorena Elizabeth

AU - Deliyannis, Georgia

AU - Hartland, Elizabeth Louise

AU - Pearse, Martin J

AU - Maloney, Margaret B

AU - Wesselingh, Steven Lodewyk

AU - Wijburg, Odilia LC

AU - Strugnell, Richard

PY - 2008

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AB - Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge with K. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimental K. pneumoniae infection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains of K. pneumoniae.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18725260

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JO - Vaccine

JF - Vaccine

SN - 0264-410X

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