Targeting plasma cells in autoimmune diseases

David M. Tarlinton, Philip D. Hodgkin

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Antibodies specific for self-antigens mediate life-threatening pathology in several autoimmune diseases. Clearly the ability to target the plasma cells (PCs) producing the autoantibodies would be of great clinical benefit. Current immunosuppressive therapies are based on the premise that autoreactive PCs are short-lived and replenished from ongoing immune responses. However, recent results question this assumption and suggest that optimizing the treatment of severe autoimmune conditions will require a significant investment in elucidating the details of PC biology.

Original languageEnglish
Pages (from-to)1451-1454
Number of pages4
JournalJournal of Experimental Medicine
Volume199
Issue number11
DOIs
Publication statusPublished - 7 Jun 2004

Cite this