Targeting of transient receptor potential channels in digestive disease

Daniel P Poole, TinaMarie Lieu, Nicholas A Veldhuis, Pradeep Rajasekhar, Nigel W Bunnett

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Transient Receptor Potential (TRP) channels are expressed throughout the gastrointestinal tract and have functional roles as detectors of taste and visceral sensation, as well as mediators of motility and secretion. Altered TRP expression or dysregulation of TRP channel function is associated with the etiology of gastrointestinal disease, including visceral pain, inflammatory bowel disease, pancreatitis and gastroesophageal reflux disease. This chapter summarizes the expression and functional roles of TRP channels in the gastrointestinal tract. The role of TRP channels in the development and maintenance of digestive diseases and the therapeutic potential of TRP channel modulators is also provided.
Original languageEnglish
Title of host publicationTRP Channels as Therapeutic Targets: From Basic Science to Clinical Use
EditorsArpad Szallasi
Place of PublicationLondon UK
PublisherElsevier
Pages385-403
Number of pages19
ISBN (Print)9780124200241
DOIs
Publication statusPublished - 2015

Keywords

  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Motility
  • Neurogenic inflammation
  • TRP channels
  • Visceral pain

Cite this

Poole, D. P., Lieu, T., Veldhuis, N. A., Rajasekhar, P., & Bunnett, N. W. (2015). Targeting of transient receptor potential channels in digestive disease. In A. Szallasi (Ed.), TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use (pp. 385-403). London UK: Elsevier. https://doi.org/10.1016/B978-0-12-420024-1.00021-7
Poole, Daniel P ; Lieu, TinaMarie ; Veldhuis, Nicholas A ; Rajasekhar, Pradeep ; Bunnett, Nigel W. / Targeting of transient receptor potential channels in digestive disease. TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. editor / Arpad Szallasi. London UK : Elsevier, 2015. pp. 385-403
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Poole, DP, Lieu, T, Veldhuis, NA, Rajasekhar, P & Bunnett, NW 2015, Targeting of transient receptor potential channels in digestive disease. in A Szallasi (ed.), TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Elsevier, London UK, pp. 385-403. https://doi.org/10.1016/B978-0-12-420024-1.00021-7

Targeting of transient receptor potential channels in digestive disease. / Poole, Daniel P; Lieu, TinaMarie; Veldhuis, Nicholas A; Rajasekhar, Pradeep; Bunnett, Nigel W.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. ed. / Arpad Szallasi. London UK : Elsevier, 2015. p. 385-403.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AU - Lieu, TinaMarie

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AB - Transient Receptor Potential (TRP) channels are expressed throughout the gastrointestinal tract and have functional roles as detectors of taste and visceral sensation, as well as mediators of motility and secretion. Altered TRP expression or dysregulation of TRP channel function is associated with the etiology of gastrointestinal disease, including visceral pain, inflammatory bowel disease, pancreatitis and gastroesophageal reflux disease. This chapter summarizes the expression and functional roles of TRP channels in the gastrointestinal tract. The role of TRP channels in the development and maintenance of digestive diseases and the therapeutic potential of TRP channel modulators is also provided.

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KW - Irritable bowel syndrome

KW - Motility

KW - Neurogenic inflammation

KW - TRP channels

KW - Visceral pain

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Poole DP, Lieu T, Veldhuis NA, Rajasekhar P, Bunnett NW. Targeting of transient receptor potential channels in digestive disease. In Szallasi A, editor, TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. London UK: Elsevier. 2015. p. 385-403 https://doi.org/10.1016/B978-0-12-420024-1.00021-7