Targeting neurodegeneration to prevent post-traumatic epilepsy

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalNeurobiology of Disease
Volume123
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Neurodegeneration
  • Neuroinflammation
  • Post-traumatic epilepsy
  • Tauopathies
  • Traumatic brain injury
  • β amyloid

Cite this

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title = "Targeting neurodegeneration to prevent post-traumatic epilepsy",
abstract = "In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.",
keywords = "Neurodegeneration, Neuroinflammation, Post-traumatic epilepsy, Tauopathies, Traumatic brain injury, β amyloid",
author = "Idrish Ali and {de Castro e Silva}, Juliana and Shijie Liu and Shultz, {Sandy R.} and Patrick Kwan and Jones, {Nigel C.} and O'Brien, {Terence J.}",
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Targeting neurodegeneration to prevent post-traumatic epilepsy. / Ali, Idrish; de Castro e Silva, Juliana; Liu, Shijie; Shultz, Sandy R.; Kwan, Patrick; Jones, Nigel C.; O'Brien, Terence J.

In: Neurobiology of Disease, Vol. 123, 03.2019, p. 100-109.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Targeting neurodegeneration to prevent post-traumatic epilepsy

AU - Ali, Idrish

AU - de Castro e Silva, Juliana

AU - Liu, Shijie

AU - Shultz, Sandy R.

AU - Kwan, Patrick

AU - Jones, Nigel C.

AU - O'Brien, Terence J.

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AB - In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

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KW - Neuroinflammation

KW - Post-traumatic epilepsy

KW - Tauopathies

KW - Traumatic brain injury

KW - β amyloid

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U2 - 10.1016/j.nbd.2018.08.006

DO - 10.1016/j.nbd.2018.08.006

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JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

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