Targeting neurodegeneration to prevent post-traumatic epilepsy

Idrish Ali, Juliana de Castro e Silva, Shijie Liu, Sandy R. Shultz, Patrick Kwan, Nigel C. Jones, Terence J. O'Brien

Research output: Contribution to journalReview ArticleResearchpeer-review

21 Citations (Scopus)


In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalNeurobiology of Disease
Publication statusPublished - Mar 2019


  • Neurodegeneration
  • Neuroinflammation
  • Post-traumatic epilepsy
  • Tauopathies
  • Traumatic brain injury
  • β amyloid

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