Targeting mitochondria-and reactive oxygen species-driven pathogenesis in diabetic nephropathy

Runa Sigrid Johanna Lindblom, Gavin Clive Higgins, Melinda T Coughlan, Judy Bettina De Haan-Klein

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Diabetic kidney disease is one of the major microvascular complications of both type 1 and type 2 diabetes mellitus. Approximately 30% of patients with diabetes experience renal complications. Current clinical therapies can only mitigate the symptoms, and delay the progression to end-stage renal disease, but do not prevent or reverse it. Oxidative stress is an important player in the pathogenesis of diabetic nephropathy. The activity of reactive oxygen and nitrogen species (ROS/NS), which are by-products of the diabetic milieu, has been found to correlate with pathological changes observed in the diabetic kidney. However, many clinical studies have failed to establish antioxidant therapy to be renoprotective. The discovery that increased ROS/NS activity is linked to mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, cellular senescence, and cell death calls for a refined approach to antioxidant therapy. It is becoming clear that mitochondria play a key role in the generation of ROS/NS and their consequences on the cellular pathways involved in apoptotic cell death in the diabetic kidney. Oxidative stress has also been associated with necrosis via induction of mitochondrial permeability transition. This review highlights the importance of mitochondria in regulating redox balance, modulating cellular responses to oxidative stress, and influencing cell death pathways in diabetic kidney disease. ROS/NS-mediated cellular dysfunction corresponds with progressive disease in the diabetic kidney, and consequently represents an important clinical target. Based on this consideration, this review also examines current therapeutic interventions to prevent ROS/NS-derived injury in the diabetic kidney. These interventions, mainly aimed at reducing or preventing mitochondrial-generated oxidative stress, improving mitochondrial antioxidant defense, and maintaining mitochondrial integrity, may deliver alternative approaches to halt or prevent diabetic kidney disease.

Original languageEnglish
Pages (from-to)134-156
Number of pages23
JournalThe Review of Diabetic Studies
Volume12
Issue number1-2
DOIs
Publication statusPublished - 2015

Keywords

  • Apoptosis
  • Diabetic nephropathy
  • Mitochondrial dysfunction
  • Necrosis
  • Reactive oxygen species

Cite this

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abstract = "Diabetic kidney disease is one of the major microvascular complications of both type 1 and type 2 diabetes mellitus. Approximately 30{\%} of patients with diabetes experience renal complications. Current clinical therapies can only mitigate the symptoms, and delay the progression to end-stage renal disease, but do not prevent or reverse it. Oxidative stress is an important player in the pathogenesis of diabetic nephropathy. The activity of reactive oxygen and nitrogen species (ROS/NS), which are by-products of the diabetic milieu, has been found to correlate with pathological changes observed in the diabetic kidney. However, many clinical studies have failed to establish antioxidant therapy to be renoprotective. The discovery that increased ROS/NS activity is linked to mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, cellular senescence, and cell death calls for a refined approach to antioxidant therapy. It is becoming clear that mitochondria play a key role in the generation of ROS/NS and their consequences on the cellular pathways involved in apoptotic cell death in the diabetic kidney. Oxidative stress has also been associated with necrosis via induction of mitochondrial permeability transition. This review highlights the importance of mitochondria in regulating redox balance, modulating cellular responses to oxidative stress, and influencing cell death pathways in diabetic kidney disease. ROS/NS-mediated cellular dysfunction corresponds with progressive disease in the diabetic kidney, and consequently represents an important clinical target. Based on this consideration, this review also examines current therapeutic interventions to prevent ROS/NS-derived injury in the diabetic kidney. These interventions, mainly aimed at reducing or preventing mitochondrial-generated oxidative stress, improving mitochondrial antioxidant defense, and maintaining mitochondrial integrity, may deliver alternative approaches to halt or prevent diabetic kidney disease.",
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Targeting mitochondria-and reactive oxygen species-driven pathogenesis in diabetic nephropathy. / Lindblom, Runa Sigrid Johanna; Higgins, Gavin Clive; Coughlan, Melinda T; De Haan-Klein, Judy Bettina.

In: The Review of Diabetic Studies, Vol. 12, No. 1-2, 2015, p. 134-156.

Research output: Contribution to journalReview ArticleResearchpeer-review

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