Targeting kinases in Plasmodium and Schistosoma: same goals, different challenges

Christian D Doerig, Christoph G Grevelding

Research output: Contribution to journalArticleResearchpeer-review

Abstract

With respect to parasite-induced infectious diseases of worldwide importance, members of the genera Plasmodium and Schistosoma are top pathogens. Nearly half a billion people suffer from malaria caused by Plasmodium spp. and schistosomiasis (bilharzia) induced by Schistosoma spp. Resistance against essentially all drugs used for malaria treatment has been reported. For schistosomiasis justified fear of upcoming resistance is discussed against the background of only one widely used drug for treatment. Research of the recent decade has demonstrated that essential steps of the biology of these and other parasites are controlled by kinases, which represent attractive targets for new-generation antiparasitic compounds. This article is part of a Special Issue entitled: Inhibitors of protein kinases.
Original languageEnglish
Pages (from-to)1637 - 1643
Number of pages7
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1854
Issue number10
DOIs
Publication statusPublished - 2015

Cite this

@article{b0b7cb39973847668391317db3f4b89a,
title = "Targeting kinases in Plasmodium and Schistosoma: same goals, different challenges",
abstract = "With respect to parasite-induced infectious diseases of worldwide importance, members of the genera Plasmodium and Schistosoma are top pathogens. Nearly half a billion people suffer from malaria caused by Plasmodium spp. and schistosomiasis (bilharzia) induced by Schistosoma spp. Resistance against essentially all drugs used for malaria treatment has been reported. For schistosomiasis justified fear of upcoming resistance is discussed against the background of only one widely used drug for treatment. Research of the recent decade has demonstrated that essential steps of the biology of these and other parasites are controlled by kinases, which represent attractive targets for new-generation antiparasitic compounds. This article is part of a Special Issue entitled: Inhibitors of protein kinases.",
author = "Doerig, {Christian D} and Grevelding, {Christoph G}",
year = "2015",
doi = "10.1016/j.bbapap.2015.03.002",
language = "English",
volume = "1854",
pages = "1637 -- 1643",
journal = "Biochimica et Biophysica Acta - Proteins and Proteomics",
issn = "1570-9639",
publisher = "Elsevier",
number = "10",

}

Targeting kinases in Plasmodium and Schistosoma: same goals, different challenges. / Doerig, Christian D; Grevelding, Christoph G.

In: Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1854, No. 10, 2015, p. 1637 - 1643.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Targeting kinases in Plasmodium and Schistosoma: same goals, different challenges

AU - Doerig, Christian D

AU - Grevelding, Christoph G

PY - 2015

Y1 - 2015

N2 - With respect to parasite-induced infectious diseases of worldwide importance, members of the genera Plasmodium and Schistosoma are top pathogens. Nearly half a billion people suffer from malaria caused by Plasmodium spp. and schistosomiasis (bilharzia) induced by Schistosoma spp. Resistance against essentially all drugs used for malaria treatment has been reported. For schistosomiasis justified fear of upcoming resistance is discussed against the background of only one widely used drug for treatment. Research of the recent decade has demonstrated that essential steps of the biology of these and other parasites are controlled by kinases, which represent attractive targets for new-generation antiparasitic compounds. This article is part of a Special Issue entitled: Inhibitors of protein kinases.

AB - With respect to parasite-induced infectious diseases of worldwide importance, members of the genera Plasmodium and Schistosoma are top pathogens. Nearly half a billion people suffer from malaria caused by Plasmodium spp. and schistosomiasis (bilharzia) induced by Schistosoma spp. Resistance against essentially all drugs used for malaria treatment has been reported. For schistosomiasis justified fear of upcoming resistance is discussed against the background of only one widely used drug for treatment. Research of the recent decade has demonstrated that essential steps of the biology of these and other parasites are controlled by kinases, which represent attractive targets for new-generation antiparasitic compounds. This article is part of a Special Issue entitled: Inhibitors of protein kinases.

UR - http://www.sciencedirect.com/science/article/pii/S1570963915000618

U2 - 10.1016/j.bbapap.2015.03.002

DO - 10.1016/j.bbapap.2015.03.002

M3 - Article

VL - 1854

SP - 1637

EP - 1643

JO - Biochimica et Biophysica Acta - Proteins and Proteomics

JF - Biochimica et Biophysica Acta - Proteins and Proteomics

SN - 1570-9639

IS - 10

ER -