Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Rodney Luwor; Andrew P. Morokoff; Stephanie Amiridis; Giovanna D’Abaco; Lucia Paradiso; Stanley S. Stylli; Hong P.T. Nguyen; Mark Tarleton; Kelly A. Young; Terence J. O’Brien; Phillip J. Robinson; Megan Chircop; Adam McCluskey; Nigel C. Jones

doi:10.1080/07357907.2019.1582060

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Rodney Luwor, Andrew P. Morokoff, Stephanie Amiridis, Giovanna D’Abaco, Lucia Paradiso, Stanley S. Stylli, Hong P.T. Nguyen, Mark Tarleton, Kelly A. Young, Terence J. O’Brien, Phillip J. Robinson, Megan Chircop, Adam McCluskey, Nigel C. Jones

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.

Original language	English
Pages (from-to)	144-155
Number of pages	12
Journal	Cancer Investigation
Volume	37
Issue number	3
DOIs	https://doi.org/10.1080/07357907.2019.1582060
Publication status	Published - 16 Mar 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer biology
Cancer stem cells
Dynamin
Glioblastoma
Invasion

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10.1080/07357907.2019.1582060

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Luwor, R., Morokoff, A. P., Amiridis, S., D’Abaco, G., Paradiso, L., Stylli, S. S., Nguyen, H. P. T., Tarleton, M., Young, K. A., O’Brien, T. J., Robinson, P. J., Chircop, M., McCluskey, A., & Jones, N. C. (2019). Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma. Cancer Investigation, 37(3), 144-155. https://doi.org/10.1080/07357907.2019.1582060

@article{e299870455e447fabb69153307d31200,

title = "Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma",

abstract = "Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.",

keywords = "Cancer biology, Cancer stem cells, Dynamin, Glioblastoma, Invasion",

author = "Rodney Luwor and Morokoff, \{Andrew P.\} and Stephanie Amiridis and Giovanna D{\textquoteright}Abaco and Lucia Paradiso and Stylli, \{Stanley S.\} and Nguyen, \{Hong P.T.\} and Mark Tarleton and Young, \{Kelly A.\} and O{\textquoteright}Brien, \{Terence J.\} and Robinson, \{Phillip J.\} and Megan Chircop and Adam McCluskey and Jones, \{Nigel C.\}",

year = "2019",

month = mar,

day = "16",

doi = "10.1080/07357907.2019.1582060",

language = "English",

volume = "37",

pages = "144--155",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor \& Francis",

number = "3",

}

Luwor, R, Morokoff, AP, Amiridis, S, D’Abaco, G, Paradiso, L, Stylli, SS, Nguyen, HPT, Tarleton, M, Young, KA, O’Brien, TJ, Robinson, PJ, Chircop, M, McCluskey, A & Jones, NC 2019, 'Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma', Cancer Investigation, vol. 37, no. 3, pp. 144-155. https://doi.org/10.1080/07357907.2019.1582060

TY - JOUR

T1 - Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2

T2 - A Novel Treatment Strategy for Glioblastoma

AU - Luwor, Rodney

AU - Morokoff, Andrew P.

AU - Amiridis, Stephanie

AU - D’Abaco, Giovanna

AU - Paradiso, Lucia

AU - Stylli, Stanley S.

AU - Nguyen, Hong P.T.

AU - Tarleton, Mark

AU - Young, Kelly A.

AU - O’Brien, Terence J.

AU - Robinson, Phillip J.

AU - Chircop, Megan

AU - McCluskey, Adam

AU - Jones, Nigel C.

PY - 2019/3/16

Y1 - 2019/3/16

N2 - Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.

AB - Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.

KW - Cancer biology

KW - Cancer stem cells

KW - Dynamin

KW - Glioblastoma

KW - Invasion

UR - https://www.scopus.com/pages/publications/85063371355

U2 - 10.1080/07357907.2019.1582060

DO - 10.1080/07357907.2019.1582060

M3 - Article

AN - SCOPUS:85063371355

SN - 0735-7907

VL - 37

SP - 144

EP - 155

JO - Cancer Investigation

JF - Cancer Investigation

IS - 3

ER -

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Abstract

UN SDGs

Keywords

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