Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2

A Novel Treatment Strategy for Glioblastoma

Rodney Luwor, Andrew P. Morokoff, Stephanie Amiridis, Giovanna D’Abaco, Lucia Paradiso, Stanley S. Stylli, Hong P.T. Nguyen, Mark Tarleton, Kelly A. Young, Terence J. O’Brien, Phillip J. Robinson, Megan Chircop, Adam McCluskey, Nigel C. Jones

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.

Original languageEnglish
Pages (from-to)144-155
Number of pages12
JournalCancer Investigation
Volume37
Issue number3
DOIs
Publication statusPublished - 16 Mar 2019

Keywords

  • Cancer biology
  • Cancer stem cells
  • Dynamin
  • Glioblastoma
  • Invasion

Cite this

Luwor, Rodney ; Morokoff, Andrew P. ; Amiridis, Stephanie ; D’Abaco, Giovanna ; Paradiso, Lucia ; Stylli, Stanley S. ; Nguyen, Hong P.T. ; Tarleton, Mark ; Young, Kelly A. ; O’Brien, Terence J. ; Robinson, Phillip J. ; Chircop, Megan ; McCluskey, Adam ; Jones, Nigel C. / Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2 : A Novel Treatment Strategy for Glioblastoma. In: Cancer Investigation. 2019 ; Vol. 37, No. 3. pp. 144-155.
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title = "Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma",
abstract = "Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.",
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author = "Rodney Luwor and Morokoff, {Andrew P.} and Stephanie Amiridis and Giovanna D’Abaco and Lucia Paradiso and Stylli, {Stanley S.} and Nguyen, {Hong P.T.} and Mark Tarleton and Young, {Kelly A.} and O’Brien, {Terence J.} and Robinson, {Phillip J.} and Megan Chircop and Adam McCluskey and Jones, {Nigel C.}",
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Luwor, R, Morokoff, AP, Amiridis, S, D’Abaco, G, Paradiso, L, Stylli, SS, Nguyen, HPT, Tarleton, M, Young, KA, O’Brien, TJ, Robinson, PJ, Chircop, M, McCluskey, A & Jones, NC 2019, 'Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma', Cancer Investigation, vol. 37, no. 3, pp. 144-155. https://doi.org/10.1080/07357907.2019.1582060

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2 : A Novel Treatment Strategy for Glioblastoma. / Luwor, Rodney; Morokoff, Andrew P.; Amiridis, Stephanie; D’Abaco, Giovanna; Paradiso, Lucia; Stylli, Stanley S.; Nguyen, Hong P.T.; Tarleton, Mark; Young, Kelly A.; O’Brien, Terence J.; Robinson, Phillip J.; Chircop, Megan; McCluskey, Adam; Jones, Nigel C.

In: Cancer Investigation, Vol. 37, No. 3, 16.03.2019, p. 144-155.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2

T2 - A Novel Treatment Strategy for Glioblastoma

AU - Luwor, Rodney

AU - Morokoff, Andrew P.

AU - Amiridis, Stephanie

AU - D’Abaco, Giovanna

AU - Paradiso, Lucia

AU - Stylli, Stanley S.

AU - Nguyen, Hong P.T.

AU - Tarleton, Mark

AU - Young, Kelly A.

AU - O’Brien, Terence J.

AU - Robinson, Phillip J.

AU - Chircop, Megan

AU - McCluskey, Adam

AU - Jones, Nigel C.

PY - 2019/3/16

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AB - Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.

KW - Cancer biology

KW - Cancer stem cells

KW - Dynamin

KW - Glioblastoma

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