Targeting fibromyalgia pain: Brain-spinal cord and peripheral contributions

Kate Louise Franklyn, Emma Kathryn Guymer, Geoffrey Owen Littlejohn

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)


Fibromyalgia (FM) is a complex chronic pain syndrome with a well-defined clinical phenotype that results from disordered central pain-related mechanisms. The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms.

Original languageEnglish
Pages (from-to)463-474
Number of pages12
JournalInternational Journal of Clinical Rheumatology
Issue number4
Publication statusPublished - Aug 2011
Externally publishedYes


  • brain
  • diffuse noxious inhibitory control
  • DNIC
  • fibromyalgia
  • pain
  • psychological
  • spinal cord
  • stress

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