Targeting fibromyalgia pain: Brain-spinal cord and peripheral contributions

Kate Louise Franklyn; Emma Kathryn Guymer; Geoffrey Owen Littlejohn

doi:10.2217/ijr.11.41

Targeting fibromyalgia pain: Brain-spinal cord and peripheral contributions

Kate Louise Franklyn, Emma Kathryn Guymer, Geoffrey Owen Littlejohn

Research output: Contribution to journal › Review Article › Other › peer-review

1 Citation (Scopus)

Abstract

Fibromyalgia (FM) is a complex chronic pain syndrome with a well-defined clinical phenotype that results from disordered central pain-related mechanisms. The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms.

Original language	English
Pages (from-to)	463-474
Number of pages	12
Journal	International Journal of Clinical Rheumatology
Volume	6
Issue number	4
DOIs	https://doi.org/10.2217/ijr.11.41
Publication status	Published - Aug 2011
Externally published	Yes

Keywords

brain
diffuse noxious inhibitory control
DNIC
fibromyalgia
pain
psychological
spinal cord
stress

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10.2217/ijr.11.41

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abstract = "Fibromyalgia (FM) is a complex chronic pain syndrome with a well-defined clinical phenotype that results from disordered central pain-related mechanisms. The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms.",

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KW - diffuse noxious inhibitory control

KW - DNIC

KW - fibromyalgia

KW - pain

KW - psychological

KW - spinal cord

KW - stress

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ER -

Targeting fibromyalgia pain: Brain-spinal cord and peripheral contributions

Abstract

Keywords

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