Targeting dendritic cells: A promising strategy to improve vaccine effectiveness

Christophe Macri, Claire Dumont, Angus PR Johnston, Justine Mintern

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets.
Original languageEnglish
Article numbere66
Number of pages8
JournalClinical and Translational Immunology
Volume5
Issue number3
DOIs
Publication statusPublished - 18 Mar 2016

Cite this

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title = "Targeting dendritic cells: A promising strategy to improve vaccine effectiveness",
abstract = "Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets.",
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Targeting dendritic cells : A promising strategy to improve vaccine effectiveness. / Macri, Christophe; Dumont, Claire ; Johnston, Angus PR; Mintern, Justine.

In: Clinical and Translational Immunology, Vol. 5, No. 3, e66, 18.03.2016.

Research output: Contribution to journalReview ArticleOtherpeer-review

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