Abstract
| Original language | English |
|---|---|
| Article number | e66 |
| Number of pages | 8 |
| Journal | Clinical and Translational Immunology |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 18 Mar 2016 |
Cite this
}
Targeting dendritic cells : A promising strategy to improve vaccine effectiveness. / Macri, Christophe; Dumont, Claire ; Johnston, Angus PR; Mintern, Justine.
In: Clinical and Translational Immunology, Vol. 5, No. 3, e66, 18.03.2016.Research output: Contribution to journal › Review Article › Other › peer-review
TY - JOUR
T1 - Targeting dendritic cells
T2 - A promising strategy to improve vaccine effectiveness
AU - Macri, Christophe
AU - Dumont, Claire
AU - Johnston, Angus PR
AU - Mintern, Justine
PY - 2016/3/18
Y1 - 2016/3/18
N2 - Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets.
AB - Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets.
UR - http://www.scopus.com/inward/record.url?scp=85003795745&partnerID=8YFLogxK
U2 - 10.1038/cti.2016.6
DO - 10.1038/cti.2016.6
M3 - Review Article
VL - 5
JO - Clinical and Translational Immunology
JF - Clinical and Translational Immunology
SN - 2050-0068
IS - 3
M1 - e66
ER -