TY - JOUR
T1 - Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization
AU - Gan, Hui K
AU - Lappas, Martha
AU - Cao, Diana X
AU - Cvrljevic, Anna Nada
AU - Scott, Andrew M
AU - Johns, Terrance Grant
PY - 2009
Y1 - 2009
N2 - Abstract Monoclonal antibodies (mAb s) and tyrosine kinase inhibitors targeting the Epidermal Growth Factor receptor (EGFR), which is often pathogenetically (over-)expressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised against de2-7EGFR (or EGFRvIII), a constitutively active mutation expressed in gliomas, but also recognizes a subset (
AB - Abstract Monoclonal antibodies (mAb s) and tyrosine kinase inhibitors targeting the Epidermal Growth Factor receptor (EGFR), which is often pathogenetically (over-)expressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised against de2-7EGFR (or EGFRvIII), a constitutively active mutation expressed in gliomas, but also recognizes a subset (
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00783.x/abstract
U2 - 10.1111/j.1582-4934.2009.00783.x
DO - 10.1111/j.1582-4934.2009.00783.x
M3 - Article
SN - 1582-1838
VL - 13
SP - 3993
EP - 4001
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
IS - 9B
ER -