Abstract
Advanced hepatocellular carcinoma is the third most common cause of cancer-related mortality worldwide. Systemic therapy has historically had limited efficacy; however, targeted therapies offer promise in improving patient outcomes. Recently, two pivotal phase III randomized double-blind trials of the oral multi-tyrosine kinase inhibitor sorafenib compared with placebo demonstrated a survival benefit in advanced hepatocellular carcinoma. Other targeted agents have also shown promising results in early-phase trials. This review examines the current knowledge about targeted therapies in advanced hepatocellular carcinoma and addresses some of the key issues for future research in this disease.
Original language | English |
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Pages (from-to) | 81-94 |
Number of pages | 14 |
Journal | Asia Pacific Journal of Oncology and Hematology |
Volume | 2 |
Issue number | 1 |
Publication status | Published - Feb 2010 |
Externally published | Yes |
Keywords
- Angiogenesis
- Growth factor
- Growth factor receptor
- Hepatocellular carcinoma
- Signal transduction pathways
- Sorafenib
- Targeted therapies