Targeted disruption of the mouse Gz-alpha gene: A role for GZ in platelet function?

K. L. Kelleher, K. I. Matthael, I. A. Hendry

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16 Citations (Scopus)

Abstract

GZ is one of nine G proteins identified in platelets and its role in these cells is unknown. Our laboratory has generated a mouse deficient in the GZ-alpha gene in the hope of determining its in vivo function. Bleeding times from the tail tip of G deficient mice was significantly longer than wild type mice. Platelet aggregation and ATP secretion did not differ between wild type and G deficient mice. When mice were presented with a thromboembolism challenge no differences were observed in the survival or mortality of wild type or G deficient mice, however a strain difference was observed. Ignoring the genetic background of a mutant mouse might lead to a misinterpretation of results and thus it is absolutely critical to take the genetic background into account when assessing any aspect of a mutant mouse.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalThrombosis and Haemostasis
Volume85
Issue number3
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • ATP secretion
  • G proteins
  • Genetically mutant mice
  • Platelet aggregation
  • Thromboembolism

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