Tapping mode atomic force microscopy investigation of poly(amidoamine) core-shell tecto(dendrimers) using carbon nanoprobes

Theodore A. Betley, Jessica A. Hessler, Almut Mecke, Mark M. Banaszak Holl, Bradford G. Orr, Srinivas Uppuluri, Donald A. Tomalia, James R. Baker

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Abstract

Carbon nanoprobes were utilized in tapping mode atomic force microscopy investigations to highlight the topographic differences between poly(amidoamine) (PAMAM) dendrimers, two-dimensional arrays of PAMAM dendrimers, and PAMAM core-shell tecto(dendrimers). The PAMAM core-shell tecto(dendrimers) used for this study consist of a shell of generation five (G5) dendrimers covalently linked to a G7 core. The volumes measured for the PAMAM core-shell tecto(dendrimers) suggest a 75-100% saturation of shell G5 dendrimers about the G7 core. This compares favorably with theoretical predictions that 12 G5 dendrimers should pack to form a shell about a G7 core. The effect of different imaging substrates was also explored. Tecto(dendrimers) imaged on hydrophobic surfaces experience a 6-fold increase in maximum peak height and a 3-fold decrease in diameter as compared to those imaged on mica. Measured volume is invariant.

Original languageEnglish
Pages (from-to)3127-3133
Number of pages7
JournalLangmuir
Volume18
Issue number8
DOIs
Publication statusPublished - 16 Apr 2002
Externally publishedYes

Cite this

Betley, T. A., Hessler, J. A., Mecke, A., Banaszak Holl, M. M., Orr, B. G., Uppuluri, S., Tomalia, D. A., & Baker, J. R. (2002). Tapping mode atomic force microscopy investigation of poly(amidoamine) core-shell tecto(dendrimers) using carbon nanoprobes. Langmuir, 18(8), 3127-3133. https://doi.org/10.1021/la025538s