Tailoring dendrimer conjugates for biomedical applications

the impact of altering hydrophobicity

Mark M. Banaszak Holl, Casey A. Dougherty, Sriram Vaidyanathan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Hydrophobicity is known to play a key role in the biological distribution of materials but is often an overlooked parameter when conjugating targeting agents, drugs, and dyes to dendrimers. This review examines the impact of hydrophobic variation in stochastically conjugated dendrimers as well as materials where synthetic methods or approaches to purification provide more controlled samples. Hydrophobic interactions are considered for three general classes: (1) terminal functional group modifications, (2) bioactive small molecules chosen to interact with receptors and proteins as targeting agents and/or drugs, and (3) imaging agents to track biological activity. Impacts on membrane interaction and cellular uptake, biodistribution, interaction with transport proteins, and pharmacokinetics are discussed. The size range of the dendrimers discussed is ~ 1–10 nm.

Original languageEnglish
Article number284
Number of pages7
JournalJournal of Nanoparticle Research
Volume20
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Dendrimer
  • Drug delivery
  • Gene delivery
  • Hydrophobicity
  • Nanomedicine

Cite this

@article{956b6418765e45e2af7c23b470db59fb,
title = "Tailoring dendrimer conjugates for biomedical applications: the impact of altering hydrophobicity",
abstract = "Hydrophobicity is known to play a key role in the biological distribution of materials but is often an overlooked parameter when conjugating targeting agents, drugs, and dyes to dendrimers. This review examines the impact of hydrophobic variation in stochastically conjugated dendrimers as well as materials where synthetic methods or approaches to purification provide more controlled samples. Hydrophobic interactions are considered for three general classes: (1) terminal functional group modifications, (2) bioactive small molecules chosen to interact with receptors and proteins as targeting agents and/or drugs, and (3) imaging agents to track biological activity. Impacts on membrane interaction and cellular uptake, biodistribution, interaction with transport proteins, and pharmacokinetics are discussed. The size range of the dendrimers discussed is ~ 1–10 nm.",
keywords = "Dendrimer, Drug delivery, Gene delivery, Hydrophobicity, Nanomedicine",
author = "{Banaszak Holl}, {Mark M.} and Dougherty, {Casey A.} and Sriram Vaidyanathan",
year = "2018",
month = "10",
day = "1",
doi = "10.1007/s11051-018-4380-6",
language = "English",
volume = "20",
journal = "Journal of Nanoparticle Research",
issn = "1388-0764",
publisher = "Springer-Verlag London Ltd.",
number = "10",

}

Tailoring dendrimer conjugates for biomedical applications : the impact of altering hydrophobicity. / Banaszak Holl, Mark M.; Dougherty, Casey A.; Vaidyanathan, Sriram.

In: Journal of Nanoparticle Research, Vol. 20, No. 10, 284, 01.10.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Tailoring dendrimer conjugates for biomedical applications

T2 - the impact of altering hydrophobicity

AU - Banaszak Holl, Mark M.

AU - Dougherty, Casey A.

AU - Vaidyanathan, Sriram

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Hydrophobicity is known to play a key role in the biological distribution of materials but is often an overlooked parameter when conjugating targeting agents, drugs, and dyes to dendrimers. This review examines the impact of hydrophobic variation in stochastically conjugated dendrimers as well as materials where synthetic methods or approaches to purification provide more controlled samples. Hydrophobic interactions are considered for three general classes: (1) terminal functional group modifications, (2) bioactive small molecules chosen to interact with receptors and proteins as targeting agents and/or drugs, and (3) imaging agents to track biological activity. Impacts on membrane interaction and cellular uptake, biodistribution, interaction with transport proteins, and pharmacokinetics are discussed. The size range of the dendrimers discussed is ~ 1–10 nm.

AB - Hydrophobicity is known to play a key role in the biological distribution of materials but is often an overlooked parameter when conjugating targeting agents, drugs, and dyes to dendrimers. This review examines the impact of hydrophobic variation in stochastically conjugated dendrimers as well as materials where synthetic methods or approaches to purification provide more controlled samples. Hydrophobic interactions are considered for three general classes: (1) terminal functional group modifications, (2) bioactive small molecules chosen to interact with receptors and proteins as targeting agents and/or drugs, and (3) imaging agents to track biological activity. Impacts on membrane interaction and cellular uptake, biodistribution, interaction with transport proteins, and pharmacokinetics are discussed. The size range of the dendrimers discussed is ~ 1–10 nm.

KW - Dendrimer

KW - Drug delivery

KW - Gene delivery

KW - Hydrophobicity

KW - Nanomedicine

UR - http://www.scopus.com/inward/record.url?scp=85055287357&partnerID=8YFLogxK

U2 - 10.1007/s11051-018-4380-6

DO - 10.1007/s11051-018-4380-6

M3 - Article

VL - 20

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

SN - 1388-0764

IS - 10

M1 - 284

ER -