Tailoring carbon nanotubes surface for gene delivery applications

Anna Cifuentes-Rius; Ana De Pablo; Victor Ramos-Pérez; Salvador Borrõs

doi:10.1002/ppap.201300167

Tailoring carbon nanotubes surface for gene delivery applications

Anna Cifuentes-Rius, Ana De Pablo, Victor Ramos-Pérez, Salvador Borrõs

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Despite promising advantages, the use of carbon nanotubes (CNTs) for biomedical applications is limited due to their low biocompatibility. This study presents the modification of CNTs by plasma polymerization using two different monomers, pentafluorophenyl methacrylate (PFM) and allylamine (AA). We demonstrated that both type of monomers could be polymerized on the CNT surface in a home-built plasma reactor, allowing the formation of CNT-mediated gene delivery vectors. Once polymerized, such polymers provide different properties to the CNT surface enabling the covalent immobilization of the therapeutic gene or its binding through ionic interaction, respectively.

Original language	English
Pages (from-to)	704-713
Number of pages	10
Journal	Plasma Processes and Polymers
Volume	11
Issue number	7
DOIs	https://doi.org/10.1002/ppap.201300167
Publication status	Published - 2014
Externally published	Yes

Keywords

allylamine (AA)
carbon nanotubes (CNT)
gene delivery
pentafluorophenyl methacrylate (PFM)
plasma enhanced chemical vapor deposition (PECVD)

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10.1002/ppap.201300167

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title = "Tailoring carbon nanotubes surface for gene delivery applications",

abstract = "Despite promising advantages, the use of carbon nanotubes (CNTs) for biomedical applications is limited due to their low biocompatibility. This study presents the modification of CNTs by plasma polymerization using two different monomers, pentafluorophenyl methacrylate (PFM) and allylamine (AA). We demonstrated that both type of monomers could be polymerized on the CNT surface in a home-built plasma reactor, allowing the formation of CNT-mediated gene delivery vectors. Once polymerized, such polymers provide different properties to the CNT surface enabling the covalent immobilization of the therapeutic gene or its binding through ionic interaction, respectively. ",

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AU - Cifuentes-Rius, Anna

AU - De Pablo, Ana

AU - Ramos-Pérez, Victor

AU - Borrõs, Salvador

PY - 2014

Y1 - 2014

N2 - Despite promising advantages, the use of carbon nanotubes (CNTs) for biomedical applications is limited due to their low biocompatibility. This study presents the modification of CNTs by plasma polymerization using two different monomers, pentafluorophenyl methacrylate (PFM) and allylamine (AA). We demonstrated that both type of monomers could be polymerized on the CNT surface in a home-built plasma reactor, allowing the formation of CNT-mediated gene delivery vectors. Once polymerized, such polymers provide different properties to the CNT surface enabling the covalent immobilization of the therapeutic gene or its binding through ionic interaction, respectively.

AB - Despite promising advantages, the use of carbon nanotubes (CNTs) for biomedical applications is limited due to their low biocompatibility. This study presents the modification of CNTs by plasma polymerization using two different monomers, pentafluorophenyl methacrylate (PFM) and allylamine (AA). We demonstrated that both type of monomers could be polymerized on the CNT surface in a home-built plasma reactor, allowing the formation of CNT-mediated gene delivery vectors. Once polymerized, such polymers provide different properties to the CNT surface enabling the covalent immobilization of the therapeutic gene or its binding through ionic interaction, respectively.

KW - allylamine (AA)

KW - carbon nanotubes (CNT)

KW - gene delivery

KW - pentafluorophenyl methacrylate (PFM)

KW - plasma enhanced chemical vapor deposition (PECVD)

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DO - 10.1002/ppap.201300167

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VL - 11

SP - 704

EP - 713

JO - Plasma Processes and Polymers

JF - Plasma Processes and Polymers

IS - 7

ER -

Tailoring carbon nanotubes surface for gene delivery applications

Abstract

Keywords

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