Abstract
Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.
Original language | English |
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Pages (from-to) | 1148-1163 |
Number of pages | 16 |
Journal | Molecular Cell |
Volume | 74 |
Issue number | 6 |
DOIs | |
Publication status | Published - 20 Jun 2019 |
Keywords
- CRISPR
- ESC
- MYC
- OCT4
- TAF5L
- TAF6L
Equipment
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Biomedical Imaging (MBI)
Gary Egan (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility