TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Davide Seruggia, Martin Oti, Pratibha Tripathi, Matthew C. Canver, Lucy LeBlanc, Dafne C. Di Giammartino, Michael J. Bullen, Christian M. Nefzger, Yu Bo Yang Sun, Rick Farouni, Jose M. Polo, Luca Pinello, Effie Apostolou, Jonghwan Kim, Stuart H. Orkin, Partha Pratim Das

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

Original languageEnglish
Pages (from-to)1148-1163
Number of pages16
JournalMolecular Cell
Volume74
Issue number6
DOIs
Publication statusPublished - 20 Jun 2019

Keywords

  • CRISPR
  • ESC
  • MYC
  • OCT4
  • TAF5L
  • TAF6L

Cite this

Seruggia, Davide ; Oti, Martin ; Tripathi, Pratibha ; Canver, Matthew C. ; LeBlanc, Lucy ; Di Giammartino, Dafne C. ; Bullen, Michael J. ; Nefzger, Christian M. ; Sun, Yu Bo Yang ; Farouni, Rick ; Polo, Jose M. ; Pinello, Luca ; Apostolou, Effie ; Kim, Jonghwan ; Orkin, Stuart H. ; Das, Partha Pratim. / TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. In: Molecular Cell. 2019 ; Vol. 74, No. 6. pp. 1148-1163.
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abstract = "Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.",
keywords = "CRISPR, ESC, MYC, OCT4, TAF5L, TAF6L",
author = "Davide Seruggia and Martin Oti and Pratibha Tripathi and Canver, {Matthew C.} and Lucy LeBlanc and {Di Giammartino}, {Dafne C.} and Bullen, {Michael J.} and Nefzger, {Christian M.} and Sun, {Yu Bo Yang} and Rick Farouni and Polo, {Jose M.} and Luca Pinello and Effie Apostolou and Jonghwan Kim and Orkin, {Stuart H.} and Das, {Partha Pratim}",
year = "2019",
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Seruggia, D, Oti, M, Tripathi, P, Canver, MC, LeBlanc, L, Di Giammartino, DC, Bullen, MJ, Nefzger, CM, Sun, YBY, Farouni, R, Polo, JM, Pinello, L, Apostolou, E, Kim, J, Orkin, SH & Das, PP 2019, 'TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network', Molecular Cell, vol. 74, no. 6, pp. 1148-1163. https://doi.org/10.1016/j.molcel.2019.03.025

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. / Seruggia, Davide; Oti, Martin; Tripathi, Pratibha; Canver, Matthew C.; LeBlanc, Lucy; Di Giammartino, Dafne C.; Bullen, Michael J.; Nefzger, Christian M.; Sun, Yu Bo Yang; Farouni, Rick; Polo, Jose M.; Pinello, Luca; Apostolou, Effie; Kim, Jonghwan; Orkin, Stuart H.; Das, Partha Pratim.

In: Molecular Cell, Vol. 74, No. 6, 20.06.2019, p. 1148-1163.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

AU - Seruggia, Davide

AU - Oti, Martin

AU - Tripathi, Pratibha

AU - Canver, Matthew C.

AU - LeBlanc, Lucy

AU - Di Giammartino, Dafne C.

AU - Bullen, Michael J.

AU - Nefzger, Christian M.

AU - Sun, Yu Bo Yang

AU - Farouni, Rick

AU - Polo, Jose M.

AU - Pinello, Luca

AU - Apostolou, Effie

AU - Kim, Jonghwan

AU - Orkin, Stuart H.

AU - Das, Partha Pratim

PY - 2019/6/20

Y1 - 2019/6/20

N2 - Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

AB - Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

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KW - ESC

KW - MYC

KW - OCT4

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SN - 1097-2765

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