TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Davide Seruggia, Martin Oti, Pratibha Tripathi, Matthew C. Canver, Lucy LeBlanc, Dafne C. Di Giammartino, Michael J. Bullen, Christian M. Nefzger, Yu Bo Yang Sun, Rick Farouni, Jose M. Polo, Luca Pinello, Effie Apostolou, Jonghwan Kim, Stuart H. Orkin, Partha Pratim Das

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8 Citations (Scopus)

Abstract

Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

Original languageEnglish
Pages (from-to)1148-1163
Number of pages16
JournalMolecular Cell
Volume74
Issue number6
DOIs
Publication statusPublished - 20 Jun 2019

Keywords

  • CRISPR
  • ESC
  • MYC
  • OCT4
  • TAF5L
  • TAF6L

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