TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Davide Seruggia; Martin Oti; Pratibha Tripathi; Matthew C. Canver; Lucy LeBlanc; Dafne C. Di Giammartino; Michael J. Bullen; Christian M. Nefzger; Yu Bo Yang Sun; Rick Farouni; Jose M. Polo; Luca Pinello; Effie Apostolou; Jonghwan Kim; Stuart H. Orkin; Partha Pratim Das

doi:10.1016/j.molcel.2019.03.025

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Davide Seruggia, Martin Oti, Pratibha Tripathi, Matthew C. Canver, Lucy LeBlanc, Dafne C. Di Giammartino, Michael J. Bullen, Christian M. Nefzger, Yu Bo Yang Sun, Rick Farouni, Jose M. Polo, Luca Pinello, Effie Apostolou, Jonghwan Kim, Stuart H. Orkin, Partha Pratim Das

Research output: Contribution to journal › Article › Research › peer-review

32 Citations (Scopus)

Abstract

Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

Original language	English
Pages (from-to)	1148-1163
Number of pages	16
Journal	Molecular Cell
Volume	74
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2019.03.025
Publication status	Published - 20 Jun 2019

Keywords

CRISPR
ESC
MYC
OCT4
TAF5L
TAF6L

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10.1016/j.molcel.2019.03.025

Cite this

Seruggia, D., Oti, M., Tripathi, P., Canver, M. C., LeBlanc, L., Di Giammartino, D. C., Bullen, M. J., Nefzger, C. M., Sun, Y. B. Y., Farouni, R., Polo, J. M., Pinello, L., Apostolou, E., Kim, J., Orkin, S. H., & Das, P. P. (2019). TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Molecular Cell, 74(6), 1148-1163. https://doi.org/10.1016/j.molcel.2019.03.025

@article{7c0548aee4144c8f958c0e32be2673a2,

title = "TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network",

abstract = "Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.",

keywords = "CRISPR, ESC, MYC, OCT4, TAF5L, TAF6L",

author = "Davide Seruggia and Martin Oti and Pratibha Tripathi and Canver, {Matthew C.} and Lucy LeBlanc and {Di Giammartino}, {Dafne C.} and Bullen, {Michael J.} and Nefzger, {Christian M.} and Sun, {Yu Bo Yang} and Rick Farouni and Polo, {Jose M.} and Luca Pinello and Effie Apostolou and Jonghwan Kim and Orkin, {Stuart H.} and Das, {Partha Pratim}",

year = "2019",

month = jun,

day = "20",

doi = "10.1016/j.molcel.2019.03.025",

language = "English",

volume = "74",

pages = "1148--1163",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Elsevier",

number = "6",

}

Seruggia, D, Oti, M, Tripathi, P, Canver, MC, LeBlanc, L, Di Giammartino, DC, Bullen, MJ, Nefzger, CM, Sun, YBY, Farouni, R, Polo, JM, Pinello, L, Apostolou, E, Kim, J, Orkin, SH & Das, PP 2019, 'TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network', Molecular Cell, vol. 74, no. 6, pp. 1148-1163. https://doi.org/10.1016/j.molcel.2019.03.025

TY - JOUR

T1 - TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

AU - Seruggia, Davide

AU - Oti, Martin

AU - Tripathi, Pratibha

AU - Canver, Matthew C.

AU - LeBlanc, Lucy

AU - Di Giammartino, Dafne C.

AU - Bullen, Michael J.

AU - Nefzger, Christian M.

AU - Sun, Yu Bo Yang

AU - Farouni, Rick

AU - Polo, Jose M.

AU - Pinello, Luca

AU - Apostolou, Effie

AU - Kim, Jonghwan

AU - Orkin, Stuart H.

AU - Das, Partha Pratim

PY - 2019/6/20

Y1 - 2019/6/20

N2 - Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

AB - Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.

KW - CRISPR

KW - ESC

KW - MYC

KW - OCT4

KW - TAF5L

KW - TAF6L

UR - http://www.scopus.com/inward/record.url?scp=85067308987&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2019.03.025

DO - 10.1016/j.molcel.2019.03.025

M3 - Article

C2 - 31005419

AN - SCOPUS:85067308987

SN - 1097-2765

VL - 74

SP - 1148

EP - 1163

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Abstract

Keywords

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Other files and links

Dissecting TAF5L and TAF6L functions in embryonic stem cells, reprogramming and neurodevelopment

Biomedical Imaging (MBI)

Cite this

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Abstract

Keywords

Access to Document

Other files and links

Projects

Dissecting TAF5L and TAF6L functions in embryonic stem cells, reprogramming and neurodevelopment

Equipment

Biomedical Imaging (MBI)

Cite this