Abstract
Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.
| Original language | English |
|---|---|
| Pages (from-to) | 1148-1163 |
| Number of pages | 16 |
| Journal | Molecular Cell |
| Volume | 74 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 20 Jun 2019 |
Keywords
- CRISPR
- ESC
- MYC
- OCT4
- TAF5L
- TAF6L
Cite this
}
TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. / Seruggia, Davide; Oti, Martin; Tripathi, Pratibha; Canver, Matthew C.; LeBlanc, Lucy; Di Giammartino, Dafne C.; Bullen, Michael J.; Nefzger, Christian M.; Sun, Yu Bo Yang; Farouni, Rick; Polo, Jose M.; Pinello, Luca; Apostolou, Effie; Kim, Jonghwan; Orkin, Stuart H.; Das, Partha Pratim.
In: Molecular Cell, Vol. 74, No. 6, 20.06.2019, p. 1148-1163.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network
AU - Seruggia, Davide
AU - Oti, Martin
AU - Tripathi, Pratibha
AU - Canver, Matthew C.
AU - LeBlanc, Lucy
AU - Di Giammartino, Dafne C.
AU - Bullen, Michael J.
AU - Nefzger, Christian M.
AU - Sun, Yu Bo Yang
AU - Farouni, Rick
AU - Polo, Jose M.
AU - Pinello, Luca
AU - Apostolou, Effie
AU - Kim, Jonghwan
AU - Orkin, Stuart H.
AU - Das, Partha Pratim
PY - 2019/6/20
Y1 - 2019/6/20
N2 - Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.
AB - Seruggia et al. identify TAF5L and TAF6L as epigenetic regulators for mESC state. Both transcriptionally activate c-Myc, Oct4, and their corresponding regulatory networks. Detailed molecular analysis uncovers that TAF5L/TAF6L predominantly regulate their target genes through H3K9ac and c-MYC recruitment that activates MYC regulatory network for self-renewal of mESCs.
KW - CRISPR
KW - ESC
KW - MYC
KW - OCT4
KW - TAF5L
KW - TAF6L
UR - http://www.scopus.com/inward/record.url?scp=85067308987&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2019.03.025
DO - 10.1016/j.molcel.2019.03.025
M3 - Article
VL - 74
SP - 1148
EP - 1163
JO - Molecular Cell
JF - Molecular Cell
SN - 1097-2765
IS - 6
ER -