Tablet compression tooling – Impact of punch face edge modification

Parthiban Anbalagan, Paul Wan Sia Heng, Celine Valeria Liew

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

The influence of punch face edge geometry modification on tablet compression and the properties of the resultant tablets produced on a rotary press were investigated. The results revealed that tablets produced from the punches with radius edge face geometry consistently displayed better physical quality; higher tensile strength and lower capping tendency. Modification of the angled edge of the bevel face to the curved edge of the radius face, enabled deeper punch penetration in the die cavity during the compression cycle, bringing about greater compact densification. Improved die fill packing increased interparticulate bond formation and helped to dissipate destructive elasticity within the compact, consequently reduced tablet expansion during the decompression phase. The positive impact of punch face edge modification was also more noticeable at a higher turret speed. The application of the precompression force along with dwell time extension amplified the tableting performance of radius edge punch face design to a greater extent when compared to bevel edge punch face design. This could be attributed to the enhanced packing efficiency at both precompression and main compression stages.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume524
Issue number1-2
DOIs
Publication statusPublished - 30 May 2017
Externally publishedYes

Keywords

  • Capping
  • Powder compaction
  • Punch face
  • Tablet compression tooling

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