TY - JOUR
T1 - T1 Mapping Basic Techniques and Clinical Applications
AU - Taylor, Andrew J.
AU - Salerno, Michael
AU - Dharmakumar, Rohan
AU - Jerosch-Herold, Michael
PY - 2016/1
Y1 - 2016/1
N2 - In cardiac magnetic resonance (CMR) imaging, the T1 relaxation time for the 1H magnetization in myocardial tissue may represent a valuable biomarker for a variety of pathological conditions. This possibility has driven the growing interest in quantifying T1, rather than just relying on its effect on image contrast. The techniques have advanced to where pixel-level myocardial T1 mapping has become a routine component of CMR examinations. Combined with the use of contrast agents, T1 mapping has led an expansive investigation of interstitial remodeling in ischemic and nonischemic heart disease. The purpose of this review was to introduce the reader to the physical principles of T1 mapping, the imaging techniques developed for T1 mapping, the pathophysiological markers accessible by T1 mapping, and its clinical uses.
AB - In cardiac magnetic resonance (CMR) imaging, the T1 relaxation time for the 1H magnetization in myocardial tissue may represent a valuable biomarker for a variety of pathological conditions. This possibility has driven the growing interest in quantifying T1, rather than just relying on its effect on image contrast. The techniques have advanced to where pixel-level myocardial T1 mapping has become a routine component of CMR examinations. Combined with the use of contrast agents, T1 mapping has led an expansive investigation of interstitial remodeling in ischemic and nonischemic heart disease. The purpose of this review was to introduce the reader to the physical principles of T1 mapping, the imaging techniques developed for T1 mapping, the pathophysiological markers accessible by T1 mapping, and its clinical uses.
KW - fibrosis
KW - interstitium
KW - magnetic resonance imaging
KW - myocardium
UR - http://www.scopus.com/inward/record.url?scp=84952882248&partnerID=8YFLogxK
U2 - 10.1016/j.jcmg.2015.11.005
DO - 10.1016/j.jcmg.2015.11.005
M3 - Review Article
C2 - 26762877
AN - SCOPUS:84952882248
SN - 1936-878X
VL - 9
SP - 67
EP - 81
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 1
ER -