T lymphocytes in allergen-induced late-phase reactions and asthma

A. J. Frew, C. J. Corrigan, P. Maestrelti, J. J. Tsai, K. Kurihara, Robyn E. O’Hehir, A. Hartnett, O. Cromwell, A. B. Kay

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We have studied a number of aspects of the interrelationship between T lymphocytes and allergic inflammation. Using monoclonal antibodies and immunocytochemistry we have observed significant infiltration by CD3/VCD4+ T lymphocytes together with evidence of T cell activation in the allergen-induced late-phase skin reaction in human atopic subjects. These changes were accompanied by eosinophil infiltration and activation. Activated T cells were also detected in the blood of patients with acute severe asthma. The role of T lymphocytes in granulocyte chemotaxis and activation was also explored, using recombinant human lympho-kines, and we have identified and characterized two lymphokines which have specific effects upon neutrophils.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalInternational Archives of Allergy and Immunology
Issue number1-2
Publication statusPublished - 1 Jan 1989
Externally publishedYes

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