T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities

Florian Wiede, Thomas C. Brodnicki, Pei Kee Goh, Yew A. Leong, Gareth W. Jones, Di Yu, Alan G. Baxter, Simon A. Jones, Thomas W.H. Kay, Tony Tiganis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Genome-wide association studies have identified PTPN2 as an important non-MHC gene for autoimmunity. Single nucleotide polymorphisms that reduce PTPN2 expression have been linked with the development of various autoimmune disorders, including type 1 diabetes. The tyrosine phosphatase PTPN2 attenuates T-cell receptor and cytokine signaling in T cells to maintain peripheral tolerance, but the extent to which PTPN2 deficiency in T cells might influence type 1 diabetes onset remains unclear. NOD mice develop spontaneous autoimmune type 1 diabetes similar to that seen in humans. In this study, T-cell PTPN2 deficiency in NOD mice markedly accelerated the onset and increased the incidence of type 1 diabetes as well as that of other disorders, including colitis and Sjögren syndrome. Although PTPN2 deficiency in CD8+ T cells alone was able to drive the destruction of pancreatic b-cells and the onset of diabetes, T-cell–specific PTPN2 deficiency was also accompanied by increased CD4+ T-helper type 1 differentiation and T-follicular-helper cell polarization and increased the abundance of B cells in pancreatic islets as seen in human type 1 diabetes. These findings causally link PTPN2 deficiency in T cells with the development of type 1 diabetes and associated autoimmune comorbidities.

Original languageEnglish
Pages (from-to)1251-1266
Number of pages16
JournalDiabetes
Volume68
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

Cite this

Wiede, Florian ; Brodnicki, Thomas C. ; Goh, Pei Kee ; Leong, Yew A. ; Jones, Gareth W. ; Yu, Di ; Baxter, Alan G. ; Jones, Simon A. ; Kay, Thomas W.H. ; Tiganis, Tony. / T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities. In: Diabetes. 2019 ; Vol. 68, No. 6. pp. 1251-1266.
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title = "T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities",
abstract = "Genome-wide association studies have identified PTPN2 as an important non-MHC gene for autoimmunity. Single nucleotide polymorphisms that reduce PTPN2 expression have been linked with the development of various autoimmune disorders, including type 1 diabetes. The tyrosine phosphatase PTPN2 attenuates T-cell receptor and cytokine signaling in T cells to maintain peripheral tolerance, but the extent to which PTPN2 deficiency in T cells might influence type 1 diabetes onset remains unclear. NOD mice develop spontaneous autoimmune type 1 diabetes similar to that seen in humans. In this study, T-cell PTPN2 deficiency in NOD mice markedly accelerated the onset and increased the incidence of type 1 diabetes as well as that of other disorders, including colitis and Sj{\"o}gren syndrome. Although PTPN2 deficiency in CD8+ T cells alone was able to drive the destruction of pancreatic b-cells and the onset of diabetes, T-cell–specific PTPN2 deficiency was also accompanied by increased CD4+ T-helper type 1 differentiation and T-follicular-helper cell polarization and increased the abundance of B cells in pancreatic islets as seen in human type 1 diabetes. These findings causally link PTPN2 deficiency in T cells with the development of type 1 diabetes and associated autoimmune comorbidities.",
author = "Florian Wiede and Brodnicki, {Thomas C.} and Goh, {Pei Kee} and Leong, {Yew A.} and Jones, {Gareth W.} and Di Yu and Baxter, {Alan G.} and Jones, {Simon A.} and Kay, {Thomas W.H.} and Tony Tiganis",
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T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities. / Wiede, Florian; Brodnicki, Thomas C.; Goh, Pei Kee; Leong, Yew A.; Jones, Gareth W.; Yu, Di; Baxter, Alan G.; Jones, Simon A.; Kay, Thomas W.H.; Tiganis, Tony.

In: Diabetes, Vol. 68, No. 6, 01.06.2019, p. 1251-1266.

Research output: Contribution to journalArticleResearchpeer-review

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