Abstract
T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.
| Original language | English |
|---|---|
| Article number | 251 |
| Journal | Annals of Translational Medicine |
| Volume | 3 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 1 Oct 2015 |
Keywords
- Cancer
- Clinical trials
- Gene therapy
- T cells
- T memory stem cells (TSCM)
Cite this
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T cell therapies-are T memory stem cells the answer? / Flynn, Jacqueline K.; Gorry, Paul R.
In: Annals of Translational Medicine, Vol. 3, No. 17, 251, 01.10.2015.Research output: Contribution to journal › Editorial › Other › peer-review
TY - JOUR
T1 - T cell therapies-are T memory stem cells the answer?
AU - Flynn, Jacqueline K.
AU - Gorry, Paul R.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.
AB - T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.
KW - Cancer
KW - Clinical trials
KW - Gene therapy
KW - T cells
KW - T memory stem cells (TSCM)
UR - http://www.scopus.com/inward/record.url?scp=85015506971&partnerID=8YFLogxK
U2 - 10.3978/j.issn.2305-5839.2015.08.13
DO - 10.3978/j.issn.2305-5839.2015.08.13
M3 - Editorial
VL - 3
JO - Annals of Translational Medicine
JF - Annals of Translational Medicine
SN - 2305-5847
IS - 17
M1 - 251
ER -