T cell therapies-are T memory stem cells the answer?

Research output: Contribution to journalEditorialOtherpeer-review

Abstract

T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.

Original languageEnglish
Article number251
JournalAnnals of Translational Medicine
Volume3
Issue number17
DOIs
Publication statusPublished - 1 Oct 2015

Keywords

  • Cancer
  • Clinical trials
  • Gene therapy
  • T cells
  • T memory stem cells (TSCM)

Cite this

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title = "T cell therapies-are T memory stem cells the answer?",
abstract = "T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.",
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T cell therapies-are T memory stem cells the answer? / Flynn, Jacqueline K.; Gorry, Paul R.

In: Annals of Translational Medicine, Vol. 3, No. 17, 251, 01.10.2015.

Research output: Contribution to journalEditorialOtherpeer-review

TY - JOUR

T1 - T cell therapies-are T memory stem cells the answer?

AU - Flynn, Jacqueline K.

AU - Gorry, Paul R.

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N2 - T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.

AB - T memory stem cells (TSCM) are the earliest developmental stage of memory T cells, displaying stem cell-like properties and exhibiting a gene profile between naive and central memory (CM) T cells. Their long-lifespan, robust proliferative potential and self-renewal capacity has generated much research and clinical interest particularly for therapeutic use. Here, we discuss recent findings published in Science Translational Medicine by Biasco and colleagues [2015 Feb 4;7(273):273ra13], which provided evidence for the persistence of TSCM in humans for up to 12 years after infusion of genetically modified lymphocytes, and we examine the implications for the development of novel immunotherapies using TSCM.

KW - Cancer

KW - Clinical trials

KW - Gene therapy

KW - T cells

KW - T memory stem cells (TSCM)

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