T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions

David K. Cole; Kim M. Miles; Florian Madura; Christopher J. Holland; Andrea J. A. Schauenburg; Andrew J. Godkin; Anna M. Bulek; Anna Fuller; Hephzibah J. E. Akpovwa; Phillip G. Pymm; Nathaniel Liddy; Malkit Sami; Yi Li; Pierre J. Rizkallah; Bent K. Jakobsen; Andrew K. Sewell

doi:10.1074/jbc.M113.522110

T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions

David K. Cole, Kim M. Miles, Florian Madura, Christopher J. Holland, Andrea J. A. Schauenburg, Andrew J. Godkin, Anna M. Bulek, Anna Fuller, Hephzibah J. E. Akpovwa, Phillip G. Pymm, Nathaniel Liddy, Malkit Sami, Yi Li, Pierre J. Rizkallah, Bent K. Jakobsen, Andrew K. Sewell

Research output: Contribution to journal › Article › Research › peer-review

51 Citations (Scopus)

Abstract

Background: TCR recognition of bipartite ligands composed of self (MHC) and non-self (peptide) maintains T-cell specificity. Results: Mutation of residues in the cognate peptide override TCR mutations that enhance MHC binding. Conclusion: TCR-pMHC binding affinity requires specific TCR-peptide interactions.

Original language	English
Pages (from-to)	628-638
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	2
DOIs	https://doi.org/10.1074/jbc.M113.522110
Publication status	Published - 10 Jan 2014
Externally published	Yes

Keywords

immunology
major histocompatibility complex (MHC)
protein-protein interactions
receptor structure-function
t-cell biology
t-cell receptor

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23286499-oaFinal published version, 3.59 MB

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Cole, D. K., Miles, K. M., Madura, F., Holland, C. J., Schauenburg, A. J. A., Godkin, A. J., Bulek, A. M., Fuller, A., Akpovwa, H. J. E., Pymm, P. G., Liddy, N., Sami, M., Li, Y., Rizkallah, P. J., Jakobsen, B. K., & Sewell, A. K. (2014). T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions. Journal of Biological Chemistry, 289(2), 628-638. https://doi.org/10.1074/jbc.M113.522110

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title = "T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions",

abstract = "Background: TCR recognition of bipartite ligands composed of self (MHC) and non-self (peptide) maintains T-cell specificity. Results: Mutation of residues in the cognate peptide override TCR mutations that enhance MHC binding. Conclusion: TCR-pMHC binding affinity requires specific TCR-peptide interactions.",

keywords = "immunology, major histocompatibility complex (MHC), protein-protein interactions, receptor structure-function, t-cell biology, t-cell receptor",

author = "Cole, {David K.} and Miles, {Kim M.} and Florian Madura and Holland, {Christopher J.} and Schauenburg, {Andrea J. A.} and Godkin, {Andrew J.} and Bulek, {Anna M.} and Anna Fuller and Akpovwa, {Hephzibah J. E.} and Pymm, {Phillip G.} and Nathaniel Liddy and Malkit Sami and Yi Li and Rizkallah, {Pierre J.} and Jakobsen, {Bent K.} and Sewell, {Andrew K.}",

year = "2014",

month = jan,

day = "10",

doi = "10.1074/jbc.M113.522110",

language = "English",

volume = "289",

pages = "628--638",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology",

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Cole, DK, Miles, KM, Madura, F, Holland, CJ, Schauenburg, AJA, Godkin, AJ, Bulek, AM, Fuller, A, Akpovwa, HJE, Pymm, PG, Liddy, N, Sami, M, Li, Y, Rizkallah, PJ, Jakobsen, BK & Sewell, AK 2014, 'T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions', Journal of Biological Chemistry, vol. 289, no. 2, pp. 628-638. https://doi.org/10.1074/jbc.M113.522110

TY - JOUR

T1 - T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions

AU - Cole, David K.

AU - Miles, Kim M.

AU - Madura, Florian

AU - Holland, Christopher J.

AU - Schauenburg, Andrea J. A.

AU - Godkin, Andrew J.

AU - Bulek, Anna M.

AU - Fuller, Anna

AU - Akpovwa, Hephzibah J. E.

AU - Pymm, Phillip G.

AU - Liddy, Nathaniel

AU - Sami, Malkit

AU - Li, Yi

AU - Rizkallah, Pierre J.

AU - Jakobsen, Bent K.

AU - Sewell, Andrew K.

PY - 2014/1/10

Y1 - 2014/1/10

N2 - Background: TCR recognition of bipartite ligands composed of self (MHC) and non-self (peptide) maintains T-cell specificity. Results: Mutation of residues in the cognate peptide override TCR mutations that enhance MHC binding. Conclusion: TCR-pMHC binding affinity requires specific TCR-peptide interactions.

AB - Background: TCR recognition of bipartite ligands composed of self (MHC) and non-self (peptide) maintains T-cell specificity. Results: Mutation of residues in the cognate peptide override TCR mutations that enhance MHC binding. Conclusion: TCR-pMHC binding affinity requires specific TCR-peptide interactions.

KW - immunology

KW - major histocompatibility complex (MHC)

KW - protein-protein interactions

KW - receptor structure-function

KW - t-cell biology

KW - t-cell receptor

UR - http://www.scopus.com/inward/record.url?scp=84891939529&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.522110

DO - 10.1074/jbc.M113.522110

M3 - Article

C2 - 24196962

AN - SCOPUS:84891939529

SN - 0021-9258

VL - 289

SP - 628

EP - 638

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 2

ER -

T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions

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Keywords

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