Background: Current peptide vaccines may select suboptimal antigen-specific T-cells from polyclonal populations. Results:Acombinatorial peptide library screen was used to generate an optimal ligand that could preferentially activate a known effective T-cell clonotype. Conclusion: Rationally designed altered peptide ligands may enable the preferential selection of high quality, antigen-sensitive T-cell clonotypes. Significance: This proof-of-principle study could facilitate the development of more effective peptide vaccination strategies.
|Number of pages||13|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 26 Oct 2012|