T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting

Julia Ekeruche-Makinde; Mathew Clement; David K. Cole; Emily S J Edwards; Kristin Ladell; John J. Miles; Katherine K. Matthews; Anna Fuller; Katy A. Lloyd; Florian Madura; Garry M. Dolton; Johanne Pentier; Anna Lissina; Emma Gostick; Tiffany K. Baxter; Brian M. Baker; Pierre J. Rizkallah; David A. Price; Linda Wooldridge; Andrew K. Sewell

doi:10.1074/jbc.M112.386409

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting

Julia Ekeruche-Makinde, Mathew Clement, David K. Cole, Emily S J Edwards, Kristin Ladell, John J. Miles, Katherine K. Matthews, Anna Fuller, Katy A. Lloyd, Florian Madura, Garry M. Dolton, Johanne Pentier, Anna Lissina, Emma Gostick, Tiffany K. Baxter, Brian M. Baker, Pierre J. Rizkallah, David A. Price, Linda Wooldridge, Andrew K. Sewell

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Background: Current peptide vaccines may select suboptimal antigen-specific T-cells from polyclonal populations. Results:Acombinatorial peptide library screen was used to generate an optimal ligand that could preferentially activate a known effective T-cell clonotype. Conclusion: Rationally designed altered peptide ligands may enable the preferential selection of high quality, antigen-sensitive T-cell clonotypes. Significance: This proof-of-principle study could facilitate the development of more effective peptide vaccination strategies.

Original language	English
Pages (from-to)	37269-37281
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.386409
Publication status	Published - 26 Oct 2012
Externally published	Yes

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Ekeruche-Makinde, J., Clement, M., Cole, D. K., Edwards, E. S. J., Ladell, K., Miles, J. J., Matthews, K. K., Fuller, A., Lloyd, K. A., Madura, F., Dolton, G. M., Pentier, J., Lissina, A., Gostick, E., Baxter, T. K., Baker, B. M., Rizkallah, P. J., Price, D. A., Wooldridge, L., & Sewell, A. K. (2012). T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry, 287(44), 37269-37281. https://doi.org/10.1074/jbc.M112.386409

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title = "T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting",

abstract = "Background: Current peptide vaccines may select suboptimal antigen-specific T-cells from polyclonal populations. Results:Acombinatorial peptide library screen was used to generate an optimal ligand that could preferentially activate a known effective T-cell clonotype. Conclusion: Rationally designed altered peptide ligands may enable the preferential selection of high quality, antigen-sensitive T-cell clonotypes. Significance: This proof-of-principle study could facilitate the development of more effective peptide vaccination strategies.",

author = "Julia Ekeruche-Makinde and Mathew Clement and Cole, {David K.} and Edwards, {Emily S J} and Kristin Ladell and Miles, {John J.} and Matthews, {Katherine K.} and Anna Fuller and Lloyd, {Katy A.} and Florian Madura and Dolton, {Garry M.} and Johanne Pentier and Anna Lissina and Emma Gostick and Baxter, {Tiffany K.} and Baker, {Brian M.} and Rizkallah, {Pierre J.} and Price, {David A.} and Linda Wooldridge and Sewell, {Andrew K.}",

year = "2012",

month = oct,

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doi = "10.1074/jbc.M112.386409",

language = "English",

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Ekeruche-Makinde, J, Clement, M, Cole, DK, Edwards, ESJ, Ladell, K, Miles, JJ, Matthews, KK, Fuller, A, Lloyd, KA, Madura, F, Dolton, GM, Pentier, J, Lissina, A, Gostick, E, Baxter, TK, Baker, BM, Rizkallah, PJ, Price, DA, Wooldridge, L & Sewell, AK 2012, 'T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37269-37281. https://doi.org/10.1074/jbc.M112.386409

TY - JOUR

T1 - T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting

AU - Ekeruche-Makinde, Julia

AU - Clement, Mathew

AU - Cole, David K.

AU - Edwards, Emily S J

AU - Ladell, Kristin

AU - Miles, John J.

AU - Matthews, Katherine K.

AU - Fuller, Anna

AU - Lloyd, Katy A.

AU - Madura, Florian

AU - Dolton, Garry M.

AU - Pentier, Johanne

AU - Lissina, Anna

AU - Gostick, Emma

AU - Baxter, Tiffany K.

AU - Baker, Brian M.

AU - Rizkallah, Pierre J.

AU - Price, David A.

AU - Wooldridge, Linda

AU - Sewell, Andrew K.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Current peptide vaccines may select suboptimal antigen-specific T-cells from polyclonal populations. Results:Acombinatorial peptide library screen was used to generate an optimal ligand that could preferentially activate a known effective T-cell clonotype. Conclusion: Rationally designed altered peptide ligands may enable the preferential selection of high quality, antigen-sensitive T-cell clonotypes. Significance: This proof-of-principle study could facilitate the development of more effective peptide vaccination strategies.

AB - Background: Current peptide vaccines may select suboptimal antigen-specific T-cells from polyclonal populations. Results:Acombinatorial peptide library screen was used to generate an optimal ligand that could preferentially activate a known effective T-cell clonotype. Conclusion: Rationally designed altered peptide ligands may enable the preferential selection of high quality, antigen-sensitive T-cell clonotypes. Significance: This proof-of-principle study could facilitate the development of more effective peptide vaccination strategies.

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U2 - 10.1074/jbc.M112.386409

DO - 10.1074/jbc.M112.386409

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SN - 0021-9258

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SP - 37269

EP - 37281

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 44

ER -

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting

Abstract

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