T cell receptor bias in humans

John J. Miles, Rebekah M. Brennan, Scott R. Burrows

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)


The last decade has seen escalating reports of T cell receptor (TcR) bias across all facets of human immunity. These reports describe a phenomenon whereby certain peptide-bound major histocompatibility complexes (pMHC) elicit T cell expansions which bear TcRs with identical or near-identical sequences across unrelated individuals. These observations are indeed curious given the vastness of the naïve T cell repertoire and indicate that powerful Darwinian selection forces influence both thymic and post-thymic pMHC-driven selection. This review catalogues examples of selection bias in the human αβ T cell response and presents the proposed mechanisms that steer their supremacy in the blood.

Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalCurrent Immunology Reviews
Issue number1
Publication statusPublished - 1 Jun 2009
Externally publishedYes


  • Immunodominance
  • Major histocompatibility complex
  • Peptide
  • T cell receptor
  • T cell repertoire

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