T cell mediated immunity to influenza: Mechanisms of viral control

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Infection with influenza A virus (IAV) is a major cause of worldwide morbidity and mortality. Recent findings indicate that T cell immunity is key to limiting severity of disease arising from IAV infection, particularly in instances where antibody immunity is ineffective. As such, there is a need to understand better the mechanisms that mediate effective IAV-specific cellular immunity, especially given that T cell immunity must form an integral part of any vaccine designed to elicit crossreactive immunity against existing and new strains of influenza virus. Here, we review the current understanding of cellular immunity to IAV, highlighting recent findings that demonstrate important roles for both CD4+ and CD8+ T cell immunity in protection from IAV-mediated disease.

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalTrends in Immunology
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 2014
Externally publishedYes

Keywords

  • Immunological memory MHC class I MHC class II vaccination
  • Influenza A virus

Cite this

@article{3bd7da2430a84e928147742c390f0dca,
title = "T cell mediated immunity to influenza: Mechanisms of viral control",
abstract = "Infection with influenza A virus (IAV) is a major cause of worldwide morbidity and mortality. Recent findings indicate that T cell immunity is key to limiting severity of disease arising from IAV infection, particularly in instances where antibody immunity is ineffective. As such, there is a need to understand better the mechanisms that mediate effective IAV-specific cellular immunity, especially given that T cell immunity must form an integral part of any vaccine designed to elicit crossreactive immunity against existing and new strains of influenza virus. Here, we review the current understanding of cellular immunity to IAV, highlighting recent findings that demonstrate important roles for both CD4+ and CD8+ T cell immunity in protection from IAV-mediated disease.",
keywords = "Immunological memory MHC class I MHC class II vaccination, Influenza A virus",
author = "{La Gruta}, {Nicole L.} and Turner, {Stephen J.}",
year = "2014",
month = "8",
doi = "10.1016/j.it.2014.06.004",
language = "English",
volume = "35",
pages = "396--402",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier",
number = "8",

}

T cell mediated immunity to influenza : Mechanisms of viral control. / La Gruta, Nicole L.; Turner, Stephen J.

In: Trends in Immunology, Vol. 35, No. 8, 08.2014, p. 396-402.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - T cell mediated immunity to influenza

T2 - Mechanisms of viral control

AU - La Gruta, Nicole L.

AU - Turner, Stephen J.

PY - 2014/8

Y1 - 2014/8

N2 - Infection with influenza A virus (IAV) is a major cause of worldwide morbidity and mortality. Recent findings indicate that T cell immunity is key to limiting severity of disease arising from IAV infection, particularly in instances where antibody immunity is ineffective. As such, there is a need to understand better the mechanisms that mediate effective IAV-specific cellular immunity, especially given that T cell immunity must form an integral part of any vaccine designed to elicit crossreactive immunity against existing and new strains of influenza virus. Here, we review the current understanding of cellular immunity to IAV, highlighting recent findings that demonstrate important roles for both CD4+ and CD8+ T cell immunity in protection from IAV-mediated disease.

AB - Infection with influenza A virus (IAV) is a major cause of worldwide morbidity and mortality. Recent findings indicate that T cell immunity is key to limiting severity of disease arising from IAV infection, particularly in instances where antibody immunity is ineffective. As such, there is a need to understand better the mechanisms that mediate effective IAV-specific cellular immunity, especially given that T cell immunity must form an integral part of any vaccine designed to elicit crossreactive immunity against existing and new strains of influenza virus. Here, we review the current understanding of cellular immunity to IAV, highlighting recent findings that demonstrate important roles for both CD4+ and CD8+ T cell immunity in protection from IAV-mediated disease.

KW - Immunological memory MHC class I MHC class II vaccination

KW - Influenza A virus

UR - http://www.scopus.com/inward/record.url?scp=84905095220&partnerID=8YFLogxK

U2 - 10.1016/j.it.2014.06.004

DO - 10.1016/j.it.2014.06.004

M3 - Review Article

VL - 35

SP - 396

EP - 402

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 8

ER -