T-cell fate and function: PKC-θ and beyond

Benjamin J. Marsland, Manfred Kopf

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The serine/threonine-specific protein kinase C-θ (PKC-θ) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-θ signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-θ function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalTrends in Immunology
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Apr 2008
Externally publishedYes

Cite this

Marsland, Benjamin J. ; Kopf, Manfred. / T-cell fate and function : PKC-θ and beyond. In: Trends in Immunology. 2008 ; Vol. 29, No. 4. pp. 179-185.
@article{08a5adc9cf1b46a6af715144ebcb6660,
title = "T-cell fate and function: PKC-θ and beyond",
abstract = "The serine/threonine-specific protein kinase C-θ (PKC-θ) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-θ signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-θ function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.",
author = "Marsland, {Benjamin J.} and Manfred Kopf",
year = "2008",
month = "4",
day = "1",
doi = "10.1016/j.it.2008.01.005",
language = "English",
volume = "29",
pages = "179--185",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier",
number = "4",

}

T-cell fate and function : PKC-θ and beyond. / Marsland, Benjamin J.; Kopf, Manfred.

In: Trends in Immunology, Vol. 29, No. 4, 01.04.2008, p. 179-185.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - T-cell fate and function

T2 - PKC-θ and beyond

AU - Marsland, Benjamin J.

AU - Kopf, Manfred

PY - 2008/4/1

Y1 - 2008/4/1

N2 - The serine/threonine-specific protein kinase C-θ (PKC-θ) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-θ signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-θ function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.

AB - The serine/threonine-specific protein kinase C-θ (PKC-θ) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-θ signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-θ function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.

UR - http://www.scopus.com/inward/record.url?scp=41149167494&partnerID=8YFLogxK

U2 - 10.1016/j.it.2008.01.005

DO - 10.1016/j.it.2008.01.005

M3 - Review Article

VL - 29

SP - 179

EP - 185

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 4

ER -