T-cell dependence of immune response to hepatitis B antigen in mice

Isabel M. Roberts; Claude C. Bernard; Girish N. Vyas; Ian R. Mackay

doi:10.1038/254606a0

T-cell dependence of immune response to hepatitis B antigen in mice

Isabel M. Roberts, Claude C. Bernard, Girish N. Vyas, Ian R. Mackay

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Abstract

THE presence of hepatitis B surface antigen (HB_sAg) in blood is a marker of infection with hepatitis B virus (HBV). Persistence of the antigen in the blood of 'carriers' is a manifestation of proliferation of HBV in liver cells and this carrier state can be associated with various types of liver disease¹. In guinea pigs and chimpanzees, immunisation with HB _sAg in Freund's complete adjuvant (FCA) elicits a cutaneous delayed type hypersensitivity (DTH) response^2,3. It is believed that integrity of the thymus-dependent cell-mediated immune system in man is necessary for resistance to HBV, and that deficiency of cell-mediated immunity could predispose to development of the carrier state^4,5. We therefore investigated the contribution of thymus-derived cells to the immune response to HB_sAg in mice by immunisation of BALB/c mice, mice heterozygous for the nude mutant gene (nu/+), and congenitally athymic mice of the nu/nu strain, using purified HB_sAg.

Original language	English
Pages (from-to)	606-607
Number of pages	2
Journal	Nature
Volume	254
Issue number	5501
DOIs	https://doi.org/10.1038/254606a0
Publication status	Published - 1975

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title = "T-cell dependence of immune response to hepatitis B antigen in mice",

abstract = "THE presence of hepatitis B surface antigen (HBsAg) in blood is a marker of infection with hepatitis B virus (HBV). Persistence of the antigen in the blood of 'carriers' is a manifestation of proliferation of HBV in liver cells and this carrier state can be associated with various types of liver disease1. In guinea pigs and chimpanzees, immunisation with HB sAg in Freund's complete adjuvant (FCA) elicits a cutaneous delayed type hypersensitivity (DTH) response2,3. It is believed that integrity of the thymus-dependent cell-mediated immune system in man is necessary for resistance to HBV, and that deficiency of cell-mediated immunity could predispose to development of the carrier state4,5. We therefore investigated the contribution of thymus-derived cells to the immune response to HBsAg in mice by immunisation of BALB/c mice, mice heterozygous for the nude mutant gene (nu/+), and congenitally athymic mice of the nu/nu strain, using purified HBsAg.",

author = "Roberts, {Isabel M.} and Bernard, {Claude C.} and Vyas, {Girish N.} and Mackay, {Ian R.}",

year = "1975",

doi = "10.1038/254606a0",

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T1 - T-cell dependence of immune response to hepatitis B antigen in mice

AU - Roberts, Isabel M.

AU - Bernard, Claude C.

AU - Vyas, Girish N.

AU - Mackay, Ian R.

PY - 1975

Y1 - 1975

N2 - THE presence of hepatitis B surface antigen (HBsAg) in blood is a marker of infection with hepatitis B virus (HBV). Persistence of the antigen in the blood of 'carriers' is a manifestation of proliferation of HBV in liver cells and this carrier state can be associated with various types of liver disease1. In guinea pigs and chimpanzees, immunisation with HB sAg in Freund's complete adjuvant (FCA) elicits a cutaneous delayed type hypersensitivity (DTH) response2,3. It is believed that integrity of the thymus-dependent cell-mediated immune system in man is necessary for resistance to HBV, and that deficiency of cell-mediated immunity could predispose to development of the carrier state4,5. We therefore investigated the contribution of thymus-derived cells to the immune response to HBsAg in mice by immunisation of BALB/c mice, mice heterozygous for the nude mutant gene (nu/+), and congenitally athymic mice of the nu/nu strain, using purified HBsAg.

AB - THE presence of hepatitis B surface antigen (HBsAg) in blood is a marker of infection with hepatitis B virus (HBV). Persistence of the antigen in the blood of 'carriers' is a manifestation of proliferation of HBV in liver cells and this carrier state can be associated with various types of liver disease1. In guinea pigs and chimpanzees, immunisation with HB sAg in Freund's complete adjuvant (FCA) elicits a cutaneous delayed type hypersensitivity (DTH) response2,3. It is believed that integrity of the thymus-dependent cell-mediated immune system in man is necessary for resistance to HBV, and that deficiency of cell-mediated immunity could predispose to development of the carrier state4,5. We therefore investigated the contribution of thymus-derived cells to the immune response to HBsAg in mice by immunisation of BALB/c mice, mice heterozygous for the nude mutant gene (nu/+), and congenitally athymic mice of the nu/nu strain, using purified HBsAg.

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VL - 254

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JO - Nature

JF - Nature

IS - 5501

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T-cell dependence of immune response to hepatitis B antigen in mice

Abstract

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