Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 5 - 11 |
| Number of pages | 7 |
| Journal | Journal of Interferon and Cytokine Research |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 |
Cite this
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Systems biology of interferon responses. / Hertzog, Paul; Forster, Samuel; Samarajiwa, Shamith.
In: Journal of Interferon and Cytokine Research, Vol. 31, No. 1, 2011, p. 5 - 11.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Systems biology of interferon responses
AU - Hertzog, Paul
AU - Forster, Samuel
AU - Samarajiwa, Shamith
PY - 2011
Y1 - 2011
N2 - The interferons (IFNs) are a pleiotropic family of cytokines that perform fundamental functions in protecting host organisms from disease and in maintaining homeostasis. Like other multifunctional cytokines, excessive or inappropriate activity can cause toxicity and even death. Therefore, host organisms have evolved specific and highly regulated mechanisms to control the temporal and tissue specificity of production of IFNs and the selection of pathways and genes to be activated as the effectors of the IFN response in cells. There are now numerous microarray datasets available to enable a global analysis of the genes involved in the IFN response. This article describes the INTERFEROME database, which assimilates the available expression profiling data and its contents and enables the definition of IFN-regulated genes, discovery of pathways, regulatory networks, and tissue specificities of the IFN response.
AB - The interferons (IFNs) are a pleiotropic family of cytokines that perform fundamental functions in protecting host organisms from disease and in maintaining homeostasis. Like other multifunctional cytokines, excessive or inappropriate activity can cause toxicity and even death. Therefore, host organisms have evolved specific and highly regulated mechanisms to control the temporal and tissue specificity of production of IFNs and the selection of pathways and genes to be activated as the effectors of the IFN response in cells. There are now numerous microarray datasets available to enable a global analysis of the genes involved in the IFN response. This article describes the INTERFEROME database, which assimilates the available expression profiling data and its contents and enables the definition of IFN-regulated genes, discovery of pathways, regulatory networks, and tissue specificities of the IFN response.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21226606
U2 - 10.1089/jir.2010.0126
DO - 10.1089/jir.2010.0126
M3 - Article
VL - 31
SP - 5
EP - 11
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
SN - 1079-9907
IS - 1
ER -