TY - JOUR
T1 - Systems Biology
T2 - Functional analysis of natural microbial consortia using community proteomics
AU - VerBerkmoes, Nathan C.
AU - Denef, Vincent J.
AU - Hettich, Robert L.
AU - Banfield, Jillian F.
N1 - Funding Information:
Acknowledgements Funding was provided by the United States Department of Energy: Genomics: Genomes-to-Life Program, the National Science Foundation Biocomplexity Program and the NASA Astrobiology Institute. B. R. Maggard is thanked for secretarial assistance in the preparation of this manuscript. Oak Ridge National Laboratory is managed by University of Tennessee–Battelle LLC for the Department of Energy under contract DOE-AC05-00OR22725.
PY - 2009
Y1 - 2009
N2 - We know very little about the metabolic functioning and evolutionary dynamics of microbial communities. Recent advances in comprehensive, sequencing-based methods, however, are laying a molecular foundation for new insights into how microbial communities shape the Earth's biosphere. Here we explore the convergence of microbial ecology, genomics, biological mass spectrometry and informatics that form the new field of microbial community proteogenomics. We discuss the first applications of proteogenomics and its potential for studying the physiology, ecology and evolution of microbial populations and communities.
AB - We know very little about the metabolic functioning and evolutionary dynamics of microbial communities. Recent advances in comprehensive, sequencing-based methods, however, are laying a molecular foundation for new insights into how microbial communities shape the Earth's biosphere. Here we explore the convergence of microbial ecology, genomics, biological mass spectrometry and informatics that form the new field of microbial community proteogenomics. We discuss the first applications of proteogenomics and its potential for studying the physiology, ecology and evolution of microbial populations and communities.
UR - http://www.scopus.com/inward/record.url?scp=60749119754&partnerID=8YFLogxK
U2 - 10.1038/nrmicro2080
DO - 10.1038/nrmicro2080
M3 - Review Article
C2 - 19219053
AN - SCOPUS:60749119754
SN - 1740-1526
VL - 7
SP - 196
EP - 205
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 3
ER -
