TY - JOUR
T1 - Systemic inflammation and oxidative stress in adults with bronchiectasis
T2 - Association with clinical and functional features
AU - de Camargo, Anderson Alves
AU - de Castro, Rejane Agnelo Silva
AU - Vieira, Rodolfo P.
AU - Oliveira-Júnior, Manoel Carneiro
AU - de Araujo, Amanda Aparecida
AU - De Angelis, Kátia
AU - Rached, Samia Zahi
AU - Athanazio, Rodrigo Abensur
AU - Stelmach, Rafael
AU - Dal Corso, Simone
N1 - Funding Information:
This study was funded by the São Paulo Research Foundation (FAPESP) (grant numbers 2010/09732-6 and 2012/15165-2). AAC received a PhD fellowship from FAPESP (2014/01902-0), and MCOJ received a PhD fellowship from FAPESP (2014/14604-8).
Publisher Copyright:
© 2021 CLINICS.
PY - 2021
Y1 - 2021
N2 - OBJECTIVES: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity. METHODS: This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52.5±25.6%) and 42 healthy controls (age: 44±17 years, FEV1: 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured. RESULTS: Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1b, IL-6, and tumor necrosis factor-a correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity. CONCLUSIONS: Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity.
AB - OBJECTIVES: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity. METHODS: This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52.5±25.6%) and 42 healthy controls (age: 44±17 years, FEV1: 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured. RESULTS: Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1b, IL-6, and tumor necrosis factor-a correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity. CONCLUSIONS: Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity.
KW - Bronchiectasis
KW - Exercise Test
KW - Inflammation Mediators
KW - Oxidative Stress
UR - http://www.scopus.com/inward/record.url?scp=85105760385&partnerID=8YFLogxK
U2 - 10.6061/CLINICS/2021/E2474
DO - 10.6061/CLINICS/2021/E2474
M3 - Article
C2 - 33886789
AN - SCOPUS:85105760385
SN - 1807-5932
VL - 76
JO - Clinics
JF - Clinics
M1 - e2474
ER -