Systemic humoral immunity to non-typeable Haemophilus influenzae

Paul Thomas King, James Ngui, Dilini Amalka Gunawardena, Peter W Holmes, Michael Farmer, Stephen Roger Holdsworth

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Non-typeable Haemophilus influenzae (NTHi) is a major cause of respiratory but rarely systemic infection. The host defence to this bacterium has not been well defined in patients with chronic airway infection. The aim of this study was to assess the effect of humoral immunity in host defence to NTHi. Responses were measured in control and bronchiectasis subjects who had recurrent bronchial infection. Antibody and complement-mediated killing was assessed by incubating NTHi with serum and the role of the membrane-attack complex and classical/alternate pathways of complement activation measured.
Original languageEnglish
Pages (from-to)376 - 384
Number of pages9
JournalClinical and Experimental Immunology
Issue number3
Publication statusPublished - 2008

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