Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution

Lu Ke, Paolo Calzavacca, Michael John Bailey, Clive N May, Wei-qin Li, Joseph Bertolini, Rinaldo Bellomo

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5 Citations (Scopus)


BACKGROUND: Solutions with high chloride concentrations, like normal saline (NS), may adversely affect renal blood flow (RBF). We compared the systemic and renal haemodynamic effects of a bolus of NS with those of a novel isotonic solution containing a physiological concentration of chloride and sodium octanoate (SOct) in healthy conscious sheep. METHODS: We performed an experimental double-blind cross-over animal study. After chronic pulmonary and renal artery flow probe insertion, animals were randomly assigned to receive rapid intravenous infusion (1 L over 30 minutes) of either NS or SOct. Haemodynamic parameters were recorded continuously before and after treatment. RESULTS: NS and SOct had similar dilutional effects on the haematocrit. Both induced a short-lived increase in cardiac output (CO) and total peripheral conductance which dissipated by 60 minutes. However, SOct increased RBF more than NS (peak values, 213.4?34.3mL/min v 179.3?35.6mL/min; P <0.001) with a greater RBF/CO ratio (peak values, 12.2 ?3.7 v 10.6 ?3.6 ; P <0.001). CONCLUSIONS: NS and SOct appear to have similar systemic haemodynamic effects. However, OS significantly increases RBF compared with normal saline.
Original languageEnglish
Pages (from-to)29 - 33
Number of pages5
JournalCritical Care and Resuscitation
Issue number1
Publication statusPublished - 2014

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