TY - JOUR
T1 - Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution
AU - Ke, Lu
AU - Calzavacca, Paolo
AU - Bailey, Michael John
AU - May, Clive N
AU - Li, Wei-qin
AU - Bertolini, Joseph
AU - Bellomo, Rinaldo
PY - 2014
Y1 - 2014
N2 - BACKGROUND:
Solutions with high chloride concentrations, like normal saline (NS), may adversely affect renal blood flow (RBF). We compared the systemic and renal haemodynamic effects of a bolus of NS with those of a novel isotonic solution containing a physiological concentration of chloride and sodium octanoate (SOct) in healthy conscious sheep.
METHODS:
We performed an experimental double-blind cross-over animal study. After chronic pulmonary and renal artery flow probe insertion, animals were randomly assigned to receive rapid intravenous infusion (1 L over 30 minutes) of either NS or SOct. Haemodynamic parameters were recorded continuously before and after treatment.
RESULTS:
NS and SOct had similar dilutional effects on the haematocrit. Both induced a short-lived increase in cardiac output (CO) and total peripheral conductance which dissipated by 60 minutes. However, SOct increased RBF more than NS (peak values, 213.4?34.3mL/min v 179.3?35.6mL/min; P <0.001) with a greater RBF/CO ratio (peak values, 12.2 ?3.7 v 10.6 ?3.6 ; P <0.001).
CONCLUSIONS:
NS and SOct appear to have similar systemic haemodynamic effects. However, OS significantly increases RBF compared with normal saline.
AB - BACKGROUND:
Solutions with high chloride concentrations, like normal saline (NS), may adversely affect renal blood flow (RBF). We compared the systemic and renal haemodynamic effects of a bolus of NS with those of a novel isotonic solution containing a physiological concentration of chloride and sodium octanoate (SOct) in healthy conscious sheep.
METHODS:
We performed an experimental double-blind cross-over animal study. After chronic pulmonary and renal artery flow probe insertion, animals were randomly assigned to receive rapid intravenous infusion (1 L over 30 minutes) of either NS or SOct. Haemodynamic parameters were recorded continuously before and after treatment.
RESULTS:
NS and SOct had similar dilutional effects on the haematocrit. Both induced a short-lived increase in cardiac output (CO) and total peripheral conductance which dissipated by 60 minutes. However, SOct increased RBF more than NS (peak values, 213.4?34.3mL/min v 179.3?35.6mL/min; P <0.001) with a greater RBF/CO ratio (peak values, 12.2 ?3.7 v 10.6 ?3.6 ; P <0.001).
CONCLUSIONS:
NS and SOct appear to have similar systemic haemodynamic effects. However, OS significantly increases RBF compared with normal saline.
UR - http://search.informit.com.au/fullText;dn=164781181442128;res=IELHEA
M3 - Article
SN - 1441-2772
VL - 16
SP - 29
EP - 33
JO - Critical Care and Resuscitation
JF - Critical Care and Resuscitation
IS - 1
ER -