Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men

Charussri Leeyaphan; Jason J. Ong; Eric P. F. Chow; Fabian Y S Kong; Jane S. Hocking; Melanie Bissessor; Christopher K. Fairley; Marcus Chen

doi:10.3201/eid2210.160986

Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men

Charussri Leeyaphan, Jason J. Ong, Eric P. F. Chow, Fabian Y S Kong, Jane S. Hocking, Melanie Bissessor, Christopher K. Fairley, Marcus Chen

Melbourne Sexual Health Centre

Research output: Contribution to journal › Review Article › Research › peer-review

27 Citations (Scopus)

Abstract

Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I² = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.

Original language	English
Pages (from-to)	1778-1784
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	22
Issue number	10
DOIs	https://doi.org/10.3201/eid2210.160986
Publication status	Published - 1 Oct 2016

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10.3201/eid2210.160986

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title = "Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men",

abstract = "Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2 = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.",

author = "Charussri Leeyaphan and Ong, {Jason J.} and Chow, {Eric P. F.} and Kong, {Fabian Y S} and Hocking, {Jane S.} and Melanie Bissessor and Fairley, {Christopher K.} and Marcus Chen",

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AU - Leeyaphan, Charussri

AU - Ong, Jason J.

AU - Chow, Eric P. F.

AU - Kong, Fabian Y S

AU - Hocking, Jane S.

AU - Bissessor, Melanie

AU - Fairley, Christopher K.

AU - Chen, Marcus

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2 = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.

AB - Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2 = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.

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Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men

Abstract

UN SDGs

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Thinking outside the box: Economic evaluation of innovative strategies to expand HIV testing in men who have sex with men

Prevalence of Genital HPV Infection in Males Following Introduction of Universal Male HPV Vaccination

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Systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men

Abstract

UN SDGs

Access to Document

Other files and links

Projects

Thinking outside the box: Economic evaluation of innovative strategies to expand HIV testing in men who have sex with men

Prevalence of Genital HPV Infection in Males Following Introduction of Universal Male HPV Vaccination

Cite this