Projects per year
Abstract
Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2 = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.
Original language | English |
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Pages (from-to) | 1778-1784 |
Number of pages | 7 |
Journal | Emerging Infectious Diseases |
Volume | 22 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2016 |
Projects
- 2 Finished
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Thinking outside the box: Economic evaluation of innovative strategies to expand HIV testing in men who have sex with men
Ong, J. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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Prevalence of Genital HPV Infection in Males Following Introduction of Universal Male HPV Vaccination
Chow, E. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/18
Project: Research