TY - JOUR
T1 - Systematic review and meta-analysis of birth outcomes in women with polycystic ovary syndrome
AU - Bahri Khomami, Mahnaz
AU - Hashemi, Somayeh
AU - Shorakae, Soulmaz
AU - Harrison, Cheryce L.
AU - Piltonen, Terhi T.
AU - Romualdi, Daniela
AU - Tay, Chau Thien
AU - Mousa, Aya
AU - Vanky, Eszter
AU - Teede, Helena J.
N1 - Funding Information:
T.P. is supported by Novo Nordisk and Sigrid Jus\u00E9lius Foundation. E.V. is supported by Novo Nordisk and Merck as a lecturer and advisor for clinical studies. H.J.T. and A.M. are supported by NHMRC fellowships [APP#2009326 and APP#1161871, respectively]. The remaining authors declare no competing interests.
Funding Information:
We extend our gratitude to the colleagues who contributed to the initial systematic review published in 2019. While these collaborators were not directly involved in this update, their contributions to the foundational work have been instrumental in shaping the direction and scope of the current study. This work is supported by the Australian National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Women\u2019s Health in Reproductive Life (CRE-WHiRL) [APP#1171592] (H.J.T.). The funder of the study had no role in study design, data extraction, data analysis, data interpretation, writing of the manuscript, or the decision to submit the manuscript for publication.
Publisher Copyright:
© The Author(s) 2024.
PY - 2024/7/4
Y1 - 2024/7/4
N2 - It is unclear whether polycystic ovary syndrome (PCOS) is an independent risk factor for adverse birth outcomes in the offspring of affected women. Here, we investigate the association of PCOS with birth outcomes in the offspring of women with PCOS overall and by potential confounders. This systematic review and meta-analysis included 73 studies and 92,881 offspring of women with and without PCOS from inception until 13th July 2022. We report that mothers with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of preterm birth, fetal growth restriction and low birth weight are higher and mean birthweight is lower in PCOS of which a lower mean birthweight and a higher small for gestational age are probably independent of BMI. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured at pregnancy to identify risk and improve birth outcomes in the offspring.
AB - It is unclear whether polycystic ovary syndrome (PCOS) is an independent risk factor for adverse birth outcomes in the offspring of affected women. Here, we investigate the association of PCOS with birth outcomes in the offspring of women with PCOS overall and by potential confounders. This systematic review and meta-analysis included 73 studies and 92,881 offspring of women with and without PCOS from inception until 13th July 2022. We report that mothers with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of preterm birth, fetal growth restriction and low birth weight are higher and mean birthweight is lower in PCOS of which a lower mean birthweight and a higher small for gestational age are probably independent of BMI. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured at pregnancy to identify risk and improve birth outcomes in the offspring.
UR - http://www.scopus.com/inward/record.url?scp=85197514265&partnerID=8YFLogxK
U2 - 10.1038/s41467-024-49752-6
DO - 10.1038/s41467-024-49752-6
M3 - Article
C2 - 38965241
AN - SCOPUS:85197514265
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5592
ER -