Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Xuan Xue, George Pasparakis, Nigel Halliday, Klaus Winzer, Steven M. Howdle, Christopher J. Cramphorn, Neil R. Cameron, Paul M. Gardner, Benjamin G. Davis, Francisco Fernández-Trillo, Cameron Alexander

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

Original languageEnglish
Pages (from-to)9852-9856
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number42
DOIs
Publication statusPublished - 10 Oct 2011
Externally publishedYes

Keywords

  • cell adhesion
  • luminescence
  • polymers
  • quorum sensing
  • therapeutics

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