Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking

Jin Huang; Qiang Zhang; Guang Zhao Li; David M. Haddleton; Russell Wallis; Daniel Mitchell; Andreas Heise; C. Remzi Becer

doi:10.1002/marc.201300439

Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking

Jin Huang, Qiang Zhang, Guang Zhao Li, David M. Haddleton, Russell Wallis, Daniel Mitchell, Andreas Heise, C. Remzi Becer

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated. Synthetic glycopolymers and glycopolypeptides interact with lectins, which have a major role in biology. Here, the binding properties of glycopolypeptides and dendritic cell lectin, DC-SIGN, are investigated. Moreover, these structures effectively inhibit the binding between HIV glycoprotein, gp120, and DC-SIGN based on a detailed surface plasmon resonance study.

Original language	English
Pages (from-to)	1542-1546
Number of pages	5
Journal	Macromolecular Rapid Communications
Volume	34
Issue number	19
DOIs	https://doi.org/10.1002/marc.201300439
Publication status	Published - Oct 2013
Externally published	Yes

Keywords

dendritic cells
glycopolymer-lectin interactions
glycopolymers
glycopolypeptides
resonance
surface plasmon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/marc.201300439

Cite this

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title = "Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking",

abstract = "Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated. Synthetic glycopolymers and glycopolypeptides interact with lectins, which have a major role in biology. Here, the binding properties of glycopolypeptides and dendritic cell lectin, DC-SIGN, are investigated. Moreover, these structures effectively inhibit the binding between HIV glycoprotein, gp120, and DC-SIGN based on a detailed surface plasmon resonance study.",

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AU - Huang, Jin

AU - Zhang, Qiang

AU - Li, Guang Zhao

AU - Haddleton, David M.

AU - Wallis, Russell

AU - Mitchell, Daniel

AU - Heise, Andreas

AU - Remzi Becer, C.

PY - 2013/10

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AB - Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated. Synthetic glycopolymers and glycopolypeptides interact with lectins, which have a major role in biology. Here, the binding properties of glycopolypeptides and dendritic cell lectin, DC-SIGN, are investigated. Moreover, these structures effectively inhibit the binding between HIV glycoprotein, gp120, and DC-SIGN based on a detailed surface plasmon resonance study.

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KW - glycopolymer-lectin interactions

KW - glycopolymers

KW - glycopolypeptides

KW - resonance

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Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking

Abstract

Keywords

UN SDGs

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