Abstract
The natural hydroxyamides, (-)-tembamide and (-)-aegeline, and the cardiac drug (-) -denopamine have been prepared in homochiral form in good overall yield (>65%) from para - methoxy or para-allyloxybenzaldehyde by synthetic sequences involving entantioselective hydrocyanation of the aldehydes. Similar chemistry has been used to prepare analogues of the bronchodilator (-)-salbutamol both in high yield and with good enantiomeric excess.
Original language | English |
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Pages (from-to) | 13739-13752 |
Number of pages | 14 |
Journal | Tetrahedron |
Volume | 50 |
Issue number | 48 |
DOIs | |
Publication status | Published - 1 Jan 1994 |