Synthesis, X-ray crystal structure and tubulin-binding properties of a benzofuran analogue of the potent cytotoxic agent combretastatin A4

Martin G. Banwell, Bernard L. Flynn, Anthony C. Willis, Ernest Hamel

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3 Citations (Scopus)


The benzofuran (4), a ring-fused analogue of the potent antimitotic agent combretastatin A4 (1), has been prepared by a convergent route involving 5-endo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4), which has been characterized crystallographically as well as spectroscopically, is inactive as a tubulin-binding agent.

Original languageEnglish
JournalAustralian Journal of Chemistry
Issue number8
Publication statusPublished - 1 Dec 1999
Externally publishedYes

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