Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiOa2) and its application in drug delivery

Haifeng Bao, Jianping Yang, Yan Huang, Zhi Ping Xu, Na Hao, Zhangxiong Wu, Gaoqing Lu, Dongyuan Zhao

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71 Citations (Scopus)


We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core–shell nanostructures (LDH@mSiO2) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N2 sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m2 g−1), and large pore volume (∼0.22 cm3 g−1). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO2 core–shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.
Original languageEnglish
Pages (from-to)4069 - 4073
Number of pages5
Issue number10
Publication statusPublished - 2011

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