Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiOa2) and its application in drug delivery

Haifeng Bao, Jianping Yang, Yan Huang, Zhi Ping Xu, Na Hao, Zhangxiong Wu, Gaoqing Lu, Dongyuan Zhao

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core–shell nanostructures (LDH@mSiO2) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N2 sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m2 g−1), and large pore volume (∼0.22 cm3 g−1). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO2 core–shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.
Original languageEnglish
Pages (from-to)4069 - 4073
Number of pages5
JournalNanoscale
Volume3
Issue number10
DOIs
Publication statusPublished - 2011

Cite this

Bao, Haifeng ; Yang, Jianping ; Huang, Yan ; Xu, Zhi Ping ; Hao, Na ; Wu, Zhangxiong ; Lu, Gaoqing ; Zhao, Dongyuan. / Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiOa2) and its application in drug delivery. In: Nanoscale. 2011 ; Vol. 3, No. 10. pp. 4069 - 4073.
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title = "Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiOa2) and its application in drug delivery",
abstract = "We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core–shell nanostructures (LDH@mSiO2) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N2 sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m2 g−1), and large pore volume (∼0.22 cm3 g−1). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO2 core–shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.",
author = "Haifeng Bao and Jianping Yang and Yan Huang and Xu, {Zhi Ping} and Na Hao and Zhangxiong Wu and Gaoqing Lu and Dongyuan Zhao",
year = "2011",
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language = "English",
volume = "3",
pages = "4069 -- 4073",
journal = "Nanoscale",
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Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiOa2) and its application in drug delivery. / Bao, Haifeng; Yang, Jianping; Huang, Yan; Xu, Zhi Ping; Hao, Na; Wu, Zhangxiong; Lu, Gaoqing; Zhao, Dongyuan.

In: Nanoscale, Vol. 3, No. 10, 2011, p. 4069 - 4073.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiOa2) and its application in drug delivery

AU - Bao, Haifeng

AU - Yang, Jianping

AU - Huang, Yan

AU - Xu, Zhi Ping

AU - Hao, Na

AU - Wu, Zhangxiong

AU - Lu, Gaoqing

AU - Zhao, Dongyuan

PY - 2011

Y1 - 2011

N2 - We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core–shell nanostructures (LDH@mSiO2) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N2 sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m2 g−1), and large pore volume (∼0.22 cm3 g−1). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO2 core–shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.

AB - We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core–shell nanostructures (LDH@mSiO2) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N2 sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m2 g−1), and large pore volume (∼0.22 cm3 g−1). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO2 core–shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.

UR - http://dx.doi.org/10.1039/C1NR10718F

U2 - 10.1039/c1nr10718f

DO - 10.1039/c1nr10718f

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SN - 2040-3364

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