Synthesis of various glycopolymer architectures via RAFT polymerization: From block copolymers to stars

Julien Bernard; Xiaojuan Hao; Thomas P. Davis; Christopher Barner-Kowollik; Martina H. Stenzel

doi:10.1021/bm0506086

Synthesis of various glycopolymer architectures via RAFT polymerization: From block copolymers to stars

Julien Bernard, Xiaojuan Hao, Thomas P. Davis, Christopher Barner-Kowollik, Martina H. Stenzel

Research output: Contribution to journal › Article › Research › peer-review

157 Citations (Scopus)

Abstract

Well-defined linear poly(acryloyl glucosamine) (PAGA) exhibiting molar masses ranging from 3 to 120 K and low polydispersities have been prepared via reversible addition-fragmentation chain transfer polymerization (RAFT) in aqueous solution without recourse to protecting group chemistry. The livingness of the process was further demonstrated by successfully chain-extending one of these polymers with N-isopropylacrylamide affording narrow dispersed thermosensitive diblocks. This strategy of polymerization was finally extended to the preparation of glycopolymer stars from Z designed non-water-soluble trifunctional RAFT agent. After the growth of very short blocks of poly(hydroxyethyl acrylate) (DP_nbranch = 10), AGA was polymerized in aqueous solution in a controlled manner affording well-defined 3-arm glycopolymer stars.

Original language	English
Pages (from-to)	232-238
Number of pages	7
Journal	Biomacromolecules
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/bm0506086
Publication status	Published - 1 Jan 2006
Externally published	Yes

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abstract = "Well-defined linear poly(acryloyl glucosamine) (PAGA) exhibiting molar masses ranging from 3 to 120 K and low polydispersities have been prepared via reversible addition-fragmentation chain transfer polymerization (RAFT) in aqueous solution without recourse to protecting group chemistry. The livingness of the process was further demonstrated by successfully chain-extending one of these polymers with N-isopropylacrylamide affording narrow dispersed thermosensitive diblocks. This strategy of polymerization was finally extended to the preparation of glycopolymer stars from Z designed non-water-soluble trifunctional RAFT agent. After the growth of very short blocks of poly(hydroxyethyl acrylate) (DPnbranch = 10), AGA was polymerized in aqueous solution in a controlled manner affording well-defined 3-arm glycopolymer stars.",

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AU - Stenzel, Martina H.

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AB - Well-defined linear poly(acryloyl glucosamine) (PAGA) exhibiting molar masses ranging from 3 to 120 K and low polydispersities have been prepared via reversible addition-fragmentation chain transfer polymerization (RAFT) in aqueous solution without recourse to protecting group chemistry. The livingness of the process was further demonstrated by successfully chain-extending one of these polymers with N-isopropylacrylamide affording narrow dispersed thermosensitive diblocks. This strategy of polymerization was finally extended to the preparation of glycopolymer stars from Z designed non-water-soluble trifunctional RAFT agent. After the growth of very short blocks of poly(hydroxyethyl acrylate) (DPnbranch = 10), AGA was polymerized in aqueous solution in a controlled manner affording well-defined 3-arm glycopolymer stars.

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Synthesis of various glycopolymer architectures via RAFT polymerization: From block copolymers to stars

Abstract

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